Chiral 2-phenyl succinic ester derivatives have been obtained under mild conditions, in short times and with satisfactory yields by electrochemical reduction of chiral cinnamic acid derivatives under a CO2 atmosphere. When 4R-(diphenylmethyl)-oxazolidin-2-one was used as a chiral auxiliary the two diastereoisomers could be easily separated by. ash chromatography and the R-isomer was obtained as major product.
M., O., M., F., Sotgiu, G., A., I. (2005). Stereoselective electrochemical carboxylation: 2-phenylsuccinates from chiral cinnamic acid derivatives. ORGANIC & BIOMOLECULAR CHEMISTRY, 3(7), 1202-1208 [10.1039/b500570a].
Stereoselective electrochemical carboxylation: 2-phenylsuccinates from chiral cinnamic acid derivatives
SOTGIU, Giovanni;
2005-01-01
Abstract
Chiral 2-phenyl succinic ester derivatives have been obtained under mild conditions, in short times and with satisfactory yields by electrochemical reduction of chiral cinnamic acid derivatives under a CO2 atmosphere. When 4R-(diphenylmethyl)-oxazolidin-2-one was used as a chiral auxiliary the two diastereoisomers could be easily separated by. ash chromatography and the R-isomer was obtained as major product.File in questo prodotto:
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