The role in virulence of the Shigella flexneri ospB-phoN2 operon has been evaluated. Here we confirm that OspB is an effector and show that apyrase, the product of phoN2, may be a virulence factor, since it is required for efficient intercellular spreading. Apyrase may be important in a deoxynucleoside triphosphate-hydrolyzing activity-independent manner, suggesting that it may act as an interaction partner in the process of IcsA localization

Santapaola, D., F., D.C., A., P., S., U., Casalino, M.A., B., C., et al. (2006). Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread. Journal Bacteriol. JOURNAL OF BACTERIOLOGY, 188, 1620-1627 [10.1128/JB.188.45.1620-1627.2006].

Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread. Journal Bacteriol

CASALINO, Maria Assunta;
2006-01-01

Abstract

The role in virulence of the Shigella flexneri ospB-phoN2 operon has been evaluated. Here we confirm that OspB is an effector and show that apyrase, the product of phoN2, may be a virulence factor, since it is required for efficient intercellular spreading. Apyrase may be important in a deoxynucleoside triphosphate-hydrolyzing activity-independent manner, suggesting that it may act as an interaction partner in the process of IcsA localization
2006
Santapaola, D., F., D.C., A., P., S., U., Casalino, M.A., B., C., et al. (2006). Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread. Journal Bacteriol. JOURNAL OF BACTERIOLOGY, 188, 1620-1627 [10.1128/JB.188.45.1620-1627.2006].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/123546
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