Cysteine proteases represent a broad class of proteolytic enzymes widely distributed among living organisms. Although well known as typical lysosomal enzymes, cysteine proteases are actually recognized as multi-function enzymes, being involved in antigen processing and presentation, in membrane-bound protein cleavage, as well as in degradation of the cellular matrix and in processes of tissue remodeling. Very recently, it has been shown that the NO(-donor)-mediated chemical modification of the Cys catalytic residue of cysteine proteases, including Coxsackievirus and Rhinovirus cysteine proteases, crazain, Leishmania infantum cysteine protease, falcipain, papain, as well as mammalian caspases, cathepsins and calpain, blocks the enzyme activity in vitro and in vivo. Here, inhibition of representative cysteine proteases by NO(-donors) is reviewed.

Ascenzi, P., Salvati, L., Bolognesi, M., Colasanti, M., Polticelli, F., Venturini, G. (2001). Inhibition of cysteine protease activity by NO-donors RID A-4573-2009. CURRENT PROTEIN & PEPTIDE SCIENCE, 2(2), 137-153 [10.2174/1389203013381170 WC Biochemistry & Molecular Biology].

Inhibition of cysteine protease activity by NO-donors RID A-4573-2009

POLTICELLI, Fabio;
2001-01-01

Abstract

Cysteine proteases represent a broad class of proteolytic enzymes widely distributed among living organisms. Although well known as typical lysosomal enzymes, cysteine proteases are actually recognized as multi-function enzymes, being involved in antigen processing and presentation, in membrane-bound protein cleavage, as well as in degradation of the cellular matrix and in processes of tissue remodeling. Very recently, it has been shown that the NO(-donor)-mediated chemical modification of the Cys catalytic residue of cysteine proteases, including Coxsackievirus and Rhinovirus cysteine proteases, crazain, Leishmania infantum cysteine protease, falcipain, papain, as well as mammalian caspases, cathepsins and calpain, blocks the enzyme activity in vitro and in vivo. Here, inhibition of representative cysteine proteases by NO(-donors) is reviewed.
2001
Ascenzi, P., Salvati, L., Bolognesi, M., Colasanti, M., Polticelli, F., Venturini, G. (2001). Inhibition of cysteine protease activity by NO-donors RID A-4573-2009. CURRENT PROTEIN & PEPTIDE SCIENCE, 2(2), 137-153 [10.2174/1389203013381170 WC Biochemistry & Molecular Biology].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/137961
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