The principal limiting factor in the clinical acceptance of scintimammography is certainly its low sensitivity for cancers sized <1 cm, mainly due to the lack of equipment specifically designed for breast imaging. The National Institute of Nuclear Physics (INFN) has been developing a new scintillation camera based on Lanthanum tri-Bromide Cerium-doped crystal (LaBr3 :Ce), that demonstrating superior imaging performances with respect to the dedicated scintillation γ -camera that was previously developed. The proposed detector consists of continuous LaBr3 :Ce scintillator crystal coupled to a Hamamatsu H8500 Flat Panel PMT. One centimeter thick crystal has been chosen to increase crystal detection efficiency. In this paper, we propose a comparison and evaluation between lanthanum γ -camera and a Multi PSPMT camera, NaI(Tl) discrete pixel based, previously developed under IMI Italian project for technological transfer of INFN. A phantom study has been developed to test both the cameras before introducing them in clinical trials. High resolution scans produced by LaBr3 :Ce camera showed higher tumor contrast with a detailed imaging of uptake area than pixellated NaI(Tl) dedicated camera. Furthermore, with the lanthanum camera, the Signal-to-Noise Ratio (SNR) value was increased for a lesion as small as 5 mm, with a consequent strong improvement in detectability.
Pani, R., Pellegrini, R., Betti, M., De, V., G, C., M. N, B., et al. (2007). Clinical evaluation of pixellated NaI:Tl and continuous LaBr3:Ce, compact scintillation cameras for breast tumors imaging. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT, 571 1-2, 475-479.
Clinical evaluation of pixellated NaI:Tl and continuous LaBr3:Ce, compact scintillation cameras for breast tumors imaging
DE NOTARISTEFANI, Francesco
2007-01-01
Abstract
The principal limiting factor in the clinical acceptance of scintimammography is certainly its low sensitivity for cancers sized <1 cm, mainly due to the lack of equipment specifically designed for breast imaging. The National Institute of Nuclear Physics (INFN) has been developing a new scintillation camera based on Lanthanum tri-Bromide Cerium-doped crystal (LaBr3 :Ce), that demonstrating superior imaging performances with respect to the dedicated scintillation γ -camera that was previously developed. The proposed detector consists of continuous LaBr3 :Ce scintillator crystal coupled to a Hamamatsu H8500 Flat Panel PMT. One centimeter thick crystal has been chosen to increase crystal detection efficiency. In this paper, we propose a comparison and evaluation between lanthanum γ -camera and a Multi PSPMT camera, NaI(Tl) discrete pixel based, previously developed under IMI Italian project for technological transfer of INFN. A phantom study has been developed to test both the cameras before introducing them in clinical trials. High resolution scans produced by LaBr3 :Ce camera showed higher tumor contrast with a detailed imaging of uptake area than pixellated NaI(Tl) dedicated camera. Furthermore, with the lanthanum camera, the Signal-to-Noise Ratio (SNR) value was increased for a lesion as small as 5 mm, with a consequent strong improvement in detectability.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
