Nitric oxide (NO) has emerged as an important cytotoxic and cytostatic effector for a number of pathogens, including viruses, bacteria, fungi, and parasites. When the microbicidal effect of NO occurs, the NO-mediated S-nitrosylation of cysteine containing proteins (e.g., cysteine proteases) appears to be a common and widespread mechanism. This overview concerns parasitic cysteine proteases as NO targets, providing molecular bases for the parasiticidal effect of NO.

Colasanti, M., Gradoni, L., Mattu, M., Persichini, T., Salvati, L., Venturini, G., et al. (2002). Molecular bases for the anti-parasitic effect of NO. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 9, 131-134.

Molecular bases for the anti-parasitic effect of NO

COLASANTI, Marco;PERSICHINI, TIZIANA;VENTURINI, Giorgio;ASCENZI, Paolo
2002-01-01

Abstract

Nitric oxide (NO) has emerged as an important cytotoxic and cytostatic effector for a number of pathogens, including viruses, bacteria, fungi, and parasites. When the microbicidal effect of NO occurs, the NO-mediated S-nitrosylation of cysteine containing proteins (e.g., cysteine proteases) appears to be a common and widespread mechanism. This overview concerns parasitic cysteine proteases as NO targets, providing molecular bases for the parasiticidal effect of NO.
2002
Colasanti, M., Gradoni, L., Mattu, M., Persichini, T., Salvati, L., Venturini, G., et al. (2002). Molecular bases for the anti-parasitic effect of NO. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 9, 131-134.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/157502
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