The ability of many pathogenic bacteria to grow as a biofilm results in lower susceptibility to antibiotic treatments and to the host immune response, thus leading to the development of chronic infections. The understanding that biofilms can play an important role in bacterial virulence has prompted the search for inhibitors of biofilm development and of biofilm-related cellular processes. In this report, we present two examples of target-based microbiological screenings for antimicrobials endowed with anti-biofilm activity, aimed respectively to inhibition of the signal molecule cyclic di-GMP and of quorum sensing.
Leoni, L., Landini, P. (2014). Microbiological methods for target-oriented screening of biofilm inhibitors. In Donelli F. (a cura di), Methods Mol Biol. (pp. 175-186). New York : Humana Press [10.1007/978-1-4939-0467-9_12].
Microbiological methods for target-oriented screening of biofilm inhibitors
LEONI, Livia;
2014-01-01
Abstract
The ability of many pathogenic bacteria to grow as a biofilm results in lower susceptibility to antibiotic treatments and to the host immune response, thus leading to the development of chronic infections. The understanding that biofilms can play an important role in bacterial virulence has prompted the search for inhibitors of biofilm development and of biofilm-related cellular processes. In this report, we present two examples of target-based microbiological screenings for antimicrobials endowed with anti-biofilm activity, aimed respectively to inhibition of the signal molecule cyclic di-GMP and of quorum sensing.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
