The ability of many pathogenic bacteria to grow as a biofilm results in lower susceptibility to antibiotic treatments and to the host immune response, thus leading to the development of chronic infections. The understanding that biofilms can play an important role in bacterial virulence has prompted the search for inhibitors of biofilm development and of biofilm-related cellular processes. In this report, we present two examples of target-based microbiological screenings for antimicrobials endowed with anti-biofilm activity, aimed respectively to inhibition of the signal molecule cyclic di-GMP and of quorum sensing.

Leoni, L., Landini, P. (2014). Microbiological methods for target-oriented screening of biofilm inhibitors. In Donelli F. (a cura di), Methods Mol Biol. (pp. 175-186). New York : Humana Press [10.1007/978-1-4939-0467-9_12].

Microbiological methods for target-oriented screening of biofilm inhibitors

LEONI, Livia;
2014-01-01

Abstract

The ability of many pathogenic bacteria to grow as a biofilm results in lower susceptibility to antibiotic treatments and to the host immune response, thus leading to the development of chronic infections. The understanding that biofilms can play an important role in bacterial virulence has prompted the search for inhibitors of biofilm development and of biofilm-related cellular processes. In this report, we present two examples of target-based microbiological screenings for antimicrobials endowed with anti-biofilm activity, aimed respectively to inhibition of the signal molecule cyclic di-GMP and of quorum sensing.
2014
Leoni, L., Landini, P. (2014). Microbiological methods for target-oriented screening of biofilm inhibitors. In Donelli F. (a cura di), Methods Mol Biol. (pp. 175-186). New York : Humana Press [10.1007/978-1-4939-0467-9_12].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/168682
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