The reactions of (2-trimethylsilanylmethyl) alpha,beta-unsaturated carboxylic ethyl esters with NsONHCO(2)Et and CaO produce, after treatment with AcOH, alpha-methylene N-(ethoxycarbonyl) beta-amino carboxylic esters through ring opening and elimination of the trimethylsilyl group from the intermediate aziridine. By ozonization and subsequent reductive cleavage these products give the corresponding N-(ethoxycarbonyl) beta-amino alpha-hydroxy esters
GASPERI T, LORETO, M.A, TARDELLA, P.A, GAMBACORTA, et al. (2002). Amination of alpha,beta-unsaturated (2-trimethylsilanylmethyl)carboxylic esters. TETRAHEDRON LETTERS, 43, 3017-3020.
Titolo: | Amination of alpha,beta-unsaturated (2-trimethylsilanylmethyl)carboxylic esters |
Autori: | |
Data di pubblicazione: | 2002 |
Rivista: | |
Citazione: | GASPERI T, LORETO, M.A, TARDELLA, P.A, GAMBACORTA, et al. (2002). Amination of alpha,beta-unsaturated (2-trimethylsilanylmethyl)carboxylic esters. TETRAHEDRON LETTERS, 43, 3017-3020. |
Abstract: | The reactions of (2-trimethylsilanylmethyl) alpha,beta-unsaturated carboxylic ethyl esters with NsONHCO(2)Et and CaO produce, after treatment with AcOH, alpha-methylene N-(ethoxycarbonyl) beta-amino carboxylic esters through ring opening and elimination of the trimethylsilyl group from the intermediate aziridine. By ozonization and subsequent reductive cleavage these products give the corresponding N-(ethoxycarbonyl) beta-amino alpha-hydroxy esters |
Handle: | http://hdl.handle.net/11590/114865 |
Appare nelle tipologie: | 1.1 Articolo in rivista |