Here, we report the antimycobacterial activity of NCX 976, a new molecule obtained adding a NO moiety to the fluoroquinolone ciprofloxacin, on Mycobacterium tuberculosis H37Rv strain, both in a cell-free model and in infected human macrophages. Unlike unaltered ciprofloxacin, NCX976 displayed a marked activity also at low-nanomolar concentrations.
Ciccone, R., Mariani, F., Cavone, A., Persichini, T., Venturini, G., Ongini, E., et al. (2003). Inhibitory effect of NO-releasing ciprofloxacin (NCX 976) on Mycobacterium tuberculosis survival. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 47, 2299-2302 [10.1128/AAC.47.7.2299-2302.2003].
Inhibitory effect of NO-releasing ciprofloxacin (NCX 976) on Mycobacterium tuberculosis survival
PERSICHINI, TIZIANA;VENTURINI, Giorgio;COLASANTI, Marco
2003-01-01
Abstract
Here, we report the antimycobacterial activity of NCX 976, a new molecule obtained adding a NO moiety to the fluoroquinolone ciprofloxacin, on Mycobacterium tuberculosis H37Rv strain, both in a cell-free model and in infected human macrophages. Unlike unaltered ciprofloxacin, NCX976 displayed a marked activity also at low-nanomolar concentrations.File in questo prodotto:
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