The present investigation aimed to characterise the shape of dose-response curve and determining the frequency distribution of various aberration types as a function of dose and radiation quality in AG01522 primary human fibroblasts in the 0.1- to 1-Gy dose range. For this purpose, the cells were irradiated with 7.7 and 28.5 keV µm(-1) low-energy protons, 62 keV µm(-1 4)He(2+) ions (LNL Radiobiology facility) or X rays and samples collected for 24-colour mFISH analysis. X rays and 7.7 keV µm(-1) protons displayed a quadratic dose-response curve solely for total and simple exchanges, whereas for high-linear energy transfer radiations, a linear dose-response curve was observed for all the aberration categories, with the exception of complex exchanges.
Berardinelli, F., Nieri, D., TANZARELLA CCHERUBINI, R., NADAL V, D.e., Gerardi, S., Tanzarella, C., et al. (2015). mFISH ANALYSIS OF IRRADIATED HUMAN FIBROBLASTS: A COMPARISON AMONG RADIATIONS WITH DIFFERENT QUALITY IN THE LOW-DOSE RANGE. RADIATION PROTECTION DOSIMETRY, 11(1-4), 302-305 [10.1093/rpd/ncv189].
mFISH ANALYSIS OF IRRADIATED HUMAN FIBROBLASTS: A COMPARISON AMONG RADIATIONS WITH DIFFERENT QUALITY IN THE LOW-DOSE RANGE
BERARDINELLI, FRANCESCO;NIERI, DINO;TANZARELLA, CATERINA;SGURA, Antonella;ANTOCCIA, Antonio
2015-01-01
Abstract
The present investigation aimed to characterise the shape of dose-response curve and determining the frequency distribution of various aberration types as a function of dose and radiation quality in AG01522 primary human fibroblasts in the 0.1- to 1-Gy dose range. For this purpose, the cells were irradiated with 7.7 and 28.5 keV µm(-1) low-energy protons, 62 keV µm(-1 4)He(2+) ions (LNL Radiobiology facility) or X rays and samples collected for 24-colour mFISH analysis. X rays and 7.7 keV µm(-1) protons displayed a quadratic dose-response curve solely for total and simple exchanges, whereas for high-linear energy transfer radiations, a linear dose-response curve was observed for all the aberration categories, with the exception of complex exchanges.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
