In the last 15 years a growing interest in the biological effects induced by low doses of ionizing ratiation has arisen in the scientific community, due to an increasing number of experimental evidences showing a plethora of non-linear effects occuring after low-dose irradiations. In particular, hyper-radiosensitivity and induced radioresistance (HRS/IRR) have been reported after exposure to low- and high-LET radiation, in human (normal and tumoural) and other mammalian cells in vitro. In this framework, Chinese hamster V79 cells, human primary fibroblasts (HFFF2) and murine embryonic fibroblast's (MEFs) were irradiated with broad-beams beams of protons in the dose range 0.1-5.0Gy and at 1 Gy/min dose-rate. Cellular response has been evaluated in terms of cell survival, micronuclei induction, chromosomal aberrations and telomere length alterations. For comparison purpose, the same end-points were studied after X/gamma-rays irradiation.
Cherubini, R., De, N., V, ., Gerardi, S., Guryev, D., Antoccia, A., et al. (2008). Status report of a systematic investigation on low-dose ionizing radiation effects in mammalian cells. IL NUOVO CIMENTO DELLA SOCIETÀ ITALIANA DI FISICA. C, GEOPHYSICS AND SPACE PHYSICS, 31(1), 57-67 [10.1393/ncc/i2008-10280-x].
Status report of a systematic investigation on low-dose ionizing radiation effects in mammalian cells
Berardinelli F;SGURA, Antonella;
2008-01-01
Abstract
In the last 15 years a growing interest in the biological effects induced by low doses of ionizing ratiation has arisen in the scientific community, due to an increasing number of experimental evidences showing a plethora of non-linear effects occuring after low-dose irradiations. In particular, hyper-radiosensitivity and induced radioresistance (HRS/IRR) have been reported after exposure to low- and high-LET radiation, in human (normal and tumoural) and other mammalian cells in vitro. In this framework, Chinese hamster V79 cells, human primary fibroblasts (HFFF2) and murine embryonic fibroblast's (MEFs) were irradiated with broad-beams beams of protons in the dose range 0.1-5.0Gy and at 1 Gy/min dose-rate. Cellular response has been evaluated in terms of cell survival, micronuclei induction, chromosomal aberrations and telomere length alterations. For comparison purpose, the same end-points were studied after X/gamma-rays irradiation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
