The activity of NCX 972, a new molecule obtained by adding a nitric oxide (NO) moiety to metronidazole, was tested against six isolates of Entamoeba histolytica in xenic cultures. NCX 972 released NO into trophozoite cells and enhanced killing of amoebas in a dose- and time-dependent manner compared to metronidazole.
Sannella, A., Gradoni, L., Persichini, T., Ongini, E., Venturini, G., Colasanti, M. (2003). Intracellular release of nitric oxide by NCX 972, an NO-releasing metronidazole, enhances in vitro killing of Entamoeba histolytica. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 47, 2303-2306 [10.1128/AAC.47.7.2303-2306.2003].
Intracellular release of nitric oxide by NCX 972, an NO-releasing metronidazole, enhances in vitro killing of Entamoeba histolytica
PERSICHINI, TIZIANA;VENTURINI, Giorgio;COLASANTI, Marco
2003-01-01
Abstract
The activity of NCX 972, a new molecule obtained by adding a nitric oxide (NO) moiety to metronidazole, was tested against six isolates of Entamoeba histolytica in xenic cultures. NCX 972 released NO into trophozoite cells and enhanced killing of amoebas in a dose- and time-dependent manner compared to metronidazole.File in questo prodotto:
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