Here, we show that extracorporeal shock waves (ESW), at a low energy density value, quickly increase neuronal nitric oxide synthase (nNOS) activity and basal nitric oxide (NO) production in the rat glioma cell line C6. In addition, the treatment of C6 cells with ESW reverts the decrease of nNOS activity and NO production induced by a mixture of lipopolysaccharides (LPS), interferon-γ (IFN-γ) plus tumour necrosis factor-α (TNF-α). Finally, ESW treatment efficiently downregulates NF-κB activation and NF-κB-dependent gene expression, including inducible NOS and TNF-α. The present report suggests a possible molecular mechanism of the anti-inflammatory action of ESW treatment.

Ciampa, A.r., DE PRATI, A.c., Amelio, E., Cavalieri, E., Persichini, T., Colasanti, M., et al. (2005). Nitric oxide mediates anti-inflammatory action of extracorporeal shock waves. FEBS LETTERS, 579, 6839-6845 [10.1016/j.febslet.2005.11.023].

Nitric oxide mediates anti-inflammatory action of extracorporeal shock waves

PERSICHINI, TIZIANA;
2005-01-01

Abstract

Here, we show that extracorporeal shock waves (ESW), at a low energy density value, quickly increase neuronal nitric oxide synthase (nNOS) activity and basal nitric oxide (NO) production in the rat glioma cell line C6. In addition, the treatment of C6 cells with ESW reverts the decrease of nNOS activity and NO production induced by a mixture of lipopolysaccharides (LPS), interferon-γ (IFN-γ) plus tumour necrosis factor-α (TNF-α). Finally, ESW treatment efficiently downregulates NF-κB activation and NF-κB-dependent gene expression, including inducible NOS and TNF-α. The present report suggests a possible molecular mechanism of the anti-inflammatory action of ESW treatment.
2005
Ciampa, A.r., DE PRATI, A.c., Amelio, E., Cavalieri, E., Persichini, T., Colasanti, M., et al. (2005). Nitric oxide mediates anti-inflammatory action of extracorporeal shock waves. FEBS LETTERS, 579, 6839-6845 [10.1016/j.febslet.2005.11.023].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/117449
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