Numerous evidence has demonstrated the involvement in growth control of interferon (IFN) regulatory factor-1 (IRF-1), which shows tumor suppressor activity. IRF-1 is a well-studied member of the IRF transcription factors that reveals functional diversity in the regulation of cellular response by activating expression of a diverse set of target genes, depending on the cell type and on the specific stimuli. IRF-1 gene rearrangements may be a crucial point in the pathogenesis of some cancer types. Furthermore, different aspects of the tumor suppressor function of IRF-1 may be explained, at least in part, by the observations that IRF-1 is a regulator of cell cycle and apoptosis and that its inactivation accelerates cell transformation. Studies on gene knockout mice contributed greatly to the clarification of these multiple IRF-1 functions. We summarize our current knowledge of the antigrowth effect of IRF-1, focusing also on a more general involvement of IRF-1 in mediating negative regulation of cell growth induced by numerous cytokines and other biologic response modifiers.

Romeo, G., Fiorucci, G., Chiantore, M.V., Percario, Z.A., Vannucchi, S., Affabris, E. (2002). Review:IRF-1 as a negative regulator of cell proliferation. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 22(1), 39-47 [10.1089/107999002753452647].

Review:IRF-1 as a negative regulator of cell proliferation

AFFABRIS, Elisabetta
2002-01-01

Abstract

Numerous evidence has demonstrated the involvement in growth control of interferon (IFN) regulatory factor-1 (IRF-1), which shows tumor suppressor activity. IRF-1 is a well-studied member of the IRF transcription factors that reveals functional diversity in the regulation of cellular response by activating expression of a diverse set of target genes, depending on the cell type and on the specific stimuli. IRF-1 gene rearrangements may be a crucial point in the pathogenesis of some cancer types. Furthermore, different aspects of the tumor suppressor function of IRF-1 may be explained, at least in part, by the observations that IRF-1 is a regulator of cell cycle and apoptosis and that its inactivation accelerates cell transformation. Studies on gene knockout mice contributed greatly to the clarification of these multiple IRF-1 functions. We summarize our current knowledge of the antigrowth effect of IRF-1, focusing also on a more general involvement of IRF-1 in mediating negative regulation of cell growth induced by numerous cytokines and other biologic response modifiers.
2002
Romeo, G., Fiorucci, G., Chiantore, M.V., Percario, Z.A., Vannucchi, S., Affabris, E. (2002). Review:IRF-1 as a negative regulator of cell proliferation. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 22(1), 39-47 [10.1089/107999002753452647].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/117957
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