The presence of interferon (IFN) receptors on mouse Friend leukemia cells (FLC) has been investigated in binding experiments with highly purified 125I-labeled mouse alpha/beta IFN. Both IFN-resistant clones and wild-type IFN-sensitive FLC showed a specific saturable binding site for mouse IFN with a similar affinity constant. In contrast to IFN-sensitive FLC, IFN-resistant FLC variants were not inducible by IFN for double-stranded RNA-dependent 2-5A synthetase activity.

Affabris, E., Romeo, G., Belardelli, F., Jemma, C., Mechti, N., Gresser, I., et al. (1983). 2-5A synthetase activity does not increase in interferon-resistent Friend leukemia cell variants treated with alpha/beta interferon despite the presence of high-affinity interferon receptor sites. VIROLOGY, 125(2), 508-512.

2-5A synthetase activity does not increase in interferon-resistent Friend leukemia cell variants treated with alpha/beta interferon despite the presence of high-affinity interferon receptor sites

AFFABRIS, Elisabetta;
1983-01-01

Abstract

The presence of interferon (IFN) receptors on mouse Friend leukemia cells (FLC) has been investigated in binding experiments with highly purified 125I-labeled mouse alpha/beta IFN. Both IFN-resistant clones and wild-type IFN-sensitive FLC showed a specific saturable binding site for mouse IFN with a similar affinity constant. In contrast to IFN-sensitive FLC, IFN-resistant FLC variants were not inducible by IFN for double-stranded RNA-dependent 2-5A synthetase activity.
1983
Affabris, E., Romeo, G., Belardelli, F., Jemma, C., Mechti, N., Gresser, I., et al. (1983). 2-5A synthetase activity does not increase in interferon-resistent Friend leukemia cell variants treated with alpha/beta interferon despite the presence of high-affinity interferon receptor sites. VIROLOGY, 125(2), 508-512.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/119019
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