A simple electrochemical synthesis of beta-lactams has been developed using constant current electrolysis in a suitable solvent-supporting electrolyte solutions, with subsequent addition of bromoamides. The regio- and stereo-selectivity of the electrochemically-induced cyclization of bromoamides to beta-lactams, via N-C4 bond formation, has been evidenced. This synthesis avoids any addition of bases and probases and gives beta-lactams in high yields.

Feroci, M., Orsini, M., Palombi, L., Rossi, L., Inesi, A. (2005). An electrochemical alternative strategy to the synthesis of β-lactams via N-C4 bond formation. ELECTROCHIMICA ACTA, 50, 2029-2036.

An electrochemical alternative strategy to the synthesis of β-lactams via N-C4 bond formation

ORSINI, MONICA;
2005-01-01

Abstract

A simple electrochemical synthesis of beta-lactams has been developed using constant current electrolysis in a suitable solvent-supporting electrolyte solutions, with subsequent addition of bromoamides. The regio- and stereo-selectivity of the electrochemically-induced cyclization of bromoamides to beta-lactams, via N-C4 bond formation, has been evidenced. This synthesis avoids any addition of bases and probases and gives beta-lactams in high yields.
Feroci, M., Orsini, M., Palombi, L., Rossi, L., Inesi, A. (2005). An electrochemical alternative strategy to the synthesis of β-lactams via N-C4 bond formation. ELECTROCHIMICA ACTA, 50, 2029-2036.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/119212
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