The aim of this study was to identify a new putative biomarker in Salmo trutta exposed to water pollution. Variations in the levels of hepatic 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMG-CoAR), the rate-limiting enzyme of cholesterol biosynthesis, were compared to heat shock protein 70 and hypoxia inducible factor a, biomarkers of pollution exposure and lowered O2, respectively. The results confirm that HMG-CoAR levels increase in polluted water irrespective of water temperature or O2 content, indicating that HMG-CoAR could be used as a specific biomarker for water pollution.
Pallottini, V., Scalici, M., Gibertini, G., Marino, M., Trentalance, A. (2010). 3-hydroxy 3-methylglutaryl coenzyme A reductase: a new biomarker of fish exposure to water pollution. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 85, 381-384.
3-hydroxy 3-methylglutaryl coenzyme A reductase: a new biomarker of fish exposure to water pollution.
PALLOTTINI, Valentina;MARINO, Maria;
2010-01-01
Abstract
The aim of this study was to identify a new putative biomarker in Salmo trutta exposed to water pollution. Variations in the levels of hepatic 3-hydroxy 3-methylglutaryl Coenzyme A reductase (HMG-CoAR), the rate-limiting enzyme of cholesterol biosynthesis, were compared to heat shock protein 70 and hypoxia inducible factor a, biomarkers of pollution exposure and lowered O2, respectively. The results confirm that HMG-CoAR levels increase in polluted water irrespective of water temperature or O2 content, indicating that HMG-CoAR could be used as a specific biomarker for water pollution.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
