Multimeric proteins ( e. g. hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric proteins ( e. g. myoglobin) usually are assumed to be nonallosteric. However, the modulation of the functional properties of monomeric proteins by heterotropic allosteric effectors casts doubts on this assumption. Here, the allosteric properties of sperm whale myoglobin, human serum albumin, and human alpha-thrombin, generally considered as molecular models of monomeric proteins, are summarized.

Ascenzi, P., Bocedi, A., Bolli, A., Fasano, M., Notari, S., Polticelli, F. (2005). Allosteric modulation of monomeric proteins RID A-7100-2008 RID A-4573-2009. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 33(3), 169-176 [10.1002/bmb.2005.494033032470 WC Biochemistry & Molecular Biology; Education, Scientific Disciplines].

Allosteric modulation of monomeric proteins RID A-7100-2008 RID A-4573-2009

POLTICELLI, Fabio
2005-01-01

Abstract

Multimeric proteins ( e. g. hemoglobin) are considered to be the prototypes of allosteric enzymes, whereas monomeric proteins ( e. g. myoglobin) usually are assumed to be nonallosteric. However, the modulation of the functional properties of monomeric proteins by heterotropic allosteric effectors casts doubts on this assumption. Here, the allosteric properties of sperm whale myoglobin, human serum albumin, and human alpha-thrombin, generally considered as molecular models of monomeric proteins, are summarized.
Ascenzi, P., Bocedi, A., Bolli, A., Fasano, M., Notari, S., Polticelli, F. (2005). Allosteric modulation of monomeric proteins RID A-7100-2008 RID A-4573-2009. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 33(3), 169-176 [10.1002/bmb.2005.494033032470 WC Biochemistry & Molecular Biology; Education, Scientific Disciplines].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/120262
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