Chiral 2-phenyl succinic ester derivatives have been obtained under mild conditions, in short times and with satisfactory yields by electrochemical reduction of chiral cinnamic acid derivatives under a CO2 atmosphere. When 4R-(diphenylmethyl)-oxazolidin-2-one was used as a chiral auxiliary the two diastereoisomers could be easily separated by. ash chromatography and the R-isomer was obtained as major product.
Orsini, M., Feroci, M., Sotgiu, G., Inesi, A. (2005). Stereoselective electrochemical carboxylation: 2-phenylsuccinates from chiral cinnamic acid derivatives. ORGANIC & BIOMOLECULAR CHEMISTRY, 3, 1202-1208.
Stereoselective electrochemical carboxylation: 2-phenylsuccinates from chiral cinnamic acid derivatives
ORSINI, MONICA;SOTGIU, Giovanni;
2005-01-01
Abstract
Chiral 2-phenyl succinic ester derivatives have been obtained under mild conditions, in short times and with satisfactory yields by electrochemical reduction of chiral cinnamic acid derivatives under a CO2 atmosphere. When 4R-(diphenylmethyl)-oxazolidin-2-one was used as a chiral auxiliary the two diastereoisomers could be easily separated by. ash chromatography and the R-isomer was obtained as major product.File in questo prodotto:
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