The reactions of exocyclic alpha,beta-unsaturated gamma-lactones with NsONHCO(2)Et and CaO produce N-(ethoxycarbonyl) spiroaziridino gamma-lactones. By reaction with acetic acid these products give ring opening reaction and acetylated N-protected alpha-amino gamma-butyrolactones are obtained. The ring opening reaction is quantitative and highly regioselective
Gasperi, T., LORETO M., A., TARDELLA P., A., Veri, E. (2003). Synthesis of alpha-amino gamma-butirolactones derivatives by aziridination of alpha-ylidene gamma-butyrolactones. TETRAHEDRON LETTERS, 44, 4953-4953 [10.1016/S0040-4039(03)01166-3].
Synthesis of alpha-amino gamma-butirolactones derivatives by aziridination of alpha-ylidene gamma-butyrolactones
GASPERI, TECLA;
2003-01-01
Abstract
The reactions of exocyclic alpha,beta-unsaturated gamma-lactones with NsONHCO(2)Et and CaO produce N-(ethoxycarbonyl) spiroaziridino gamma-lactones. By reaction with acetic acid these products give ring opening reaction and acetylated N-protected alpha-amino gamma-butyrolactones are obtained. The ring opening reaction is quantitative and highly regioselectiveFile in questo prodotto:
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