An improved and efficient electrochemical N-acylation of chiral oxazolidin-2-ones has been achieved. The generation of the nitrogen anion is obtained under mild conditions and without addition of base or probase, by direct electrolysis of a solution of MeCN-TEAP containing the oxazolidinone. Acylation agents (acid chlorides or anhydrides) were added at the end of the electrolysis. N-Acylated products were isolated in high to excellent yields.
Feroci, M., Inesi, A., Palombi, L., Sotgiu, G. (2002). Electrogenerated base-induced N-acylation of chiral oxazolidin-2-ones. 2. JOURNAL OF ORGANIC CHEMISTRY, 67(5), 1719-1721 [10.1021/jo016323a].
Electrogenerated base-induced N-acylation of chiral oxazolidin-2-ones. 2
SOTGIU, Giovanni
2002-01-01
Abstract
An improved and efficient electrochemical N-acylation of chiral oxazolidin-2-ones has been achieved. The generation of the nitrogen anion is obtained under mild conditions and without addition of base or probase, by direct electrolysis of a solution of MeCN-TEAP containing the oxazolidinone. Acylation agents (acid chlorides or anhydrides) were added at the end of the electrolysis. N-Acylated products were isolated in high to excellent yields.File in questo prodotto:
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