Biomimetic polymer nanofibers of poly(epsilon-caprolactone) and poly(L-lactide caprolactone) copolymer were prepared by electrospinning. Modifications of the polymer nanofibers aimed at improving their biomimetic properties were performed by two different routes: (1) immobilization of an adhesion peptide, which mimicked the adhesion sequence of the extracellular matrix protein fibronectin, on the polymer surface and (2) incorporation of self-complementary oligopeptides, which showed alternated hydrophilic and hydrophobic side chain groups and was capable of generating extended ordered structures by self-assembling, into the polymer nanofibers. The structure of the polymer/peptide nanofibers was investigated by X-ray photoelectron and Fourier transform infrared spectroscopies.

IUCCI G, GHEZZO F, DANESIN R, MODESTI M, & DETTIN M (2011). Biomimetic Peptide-Enriched Electrospun Polymers: a Photoelectron and Infrared Spectroscopy Study. JOURNAL OF APPLIED POLYMER SCIENCE, 122(6), 3574-3582 [10.1002/app.34768].

Biomimetic Peptide-Enriched Electrospun Polymers: a Photoelectron and Infrared Spectroscopy Study

IUCCI, GIOVANNA;
2011

Abstract

Biomimetic polymer nanofibers of poly(epsilon-caprolactone) and poly(L-lactide caprolactone) copolymer were prepared by electrospinning. Modifications of the polymer nanofibers aimed at improving their biomimetic properties were performed by two different routes: (1) immobilization of an adhesion peptide, which mimicked the adhesion sequence of the extracellular matrix protein fibronectin, on the polymer surface and (2) incorporation of self-complementary oligopeptides, which showed alternated hydrophilic and hydrophobic side chain groups and was capable of generating extended ordered structures by self-assembling, into the polymer nanofibers. The structure of the polymer/peptide nanofibers was investigated by X-ray photoelectron and Fourier transform infrared spectroscopies.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11590/137863
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