Nitric oxide inhibits the HIV-1 reverse transcriptase activity RID A-4573-2009

Persichini, T; Colasanti, M; Fraziano, M; Colizzi, V; Medana, C; Polticelli, Fabio; Venturini, G; Ascenzi, P.

doi:10.1006/bbrc.1999.0581 WC Biochemistry & Molecular Biology; Biophysics

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Nitric oxide (NO) is a polypotent regulatory molecule involved in a variety of activities, such as the modulation of the catalytic activity of cysteine-containing enzymes. The present study reports the modulation of the HIV-1 reverse transcriptase activity by NO, released by the NO donors 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC-18), (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]5-nitro-3-hexenamide (NOR-3), 3-morpholinosydnonimine (SIN-1), 4-(phenylsulfonyl)-3-((2-(dimethylamino) ethyl)thio)furoxan oxalate (SNO-102), and sodium nitroprusside (SNP). NO inhibits dose-dependently the HIV-1 reverse transcriptase activity, Likely due to oxidation of Cys residue(s). Present results, representing a new insight into the modulation mechanism of the HIV-1 reverse transcriptase activity, may be relevant to develop new strategies for inhibition of HIV-1 replication. (C) 1999 Academic Press.

Titolo:	Nitric oxide inhibits the HIV-1 reverse transcriptase activity RID A-4573-2009
Autori:	Persichini T Colasanti M Fraziano M Colizzi V Medana C POLTICELLI, Fabio Venturini G Ascenzi P. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1999
Rivista:	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Citazione:	Nitric oxide inhibits the HIV-1 reverse transcriptase activity RID A-4573-2009 / Persichini T; Colasanti M; Fraziano M; Colizzi V; Medana C; Polticelli F; Venturini G; Ascenzi P. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - 258:3(1999), pp. 624-627.
Abstract:	Nitric oxide (NO) is a polypotent regulatory molecule involved in a variety of activities, such as the modulation of the catalytic activity of cysteine-containing enzymes. The present study reports the modulation of the HIV-1 reverse transcriptase activity by NO, released by the NO donors 3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC-18), (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]5-nitro-3-hexenamide (NOR-3), 3-morpholinosydnonimine (SIN-1), 4-(phenylsulfonyl)-3-((2-(dimethylamino) ethyl)thio)furoxan oxalate (SNO-102), and sodium nitroprusside (SNP). NO inhibits dose-dependently the HIV-1 reverse transcriptase activity, Likely due to oxidation of Cys residue(s). Present results, representing a new insight into the modulation mechanism of the HIV-1 reverse transcriptase activity, may be relevant to develop new strategies for inhibition of HIV-1 replication. (C) 1999 Academic Press.
Handle:	http://hdl.handle.net/11590/137964
Appare nelle tipologie:	1.1 Articolo in rivista

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