Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon.

Frangipani, E., Bonchi, C., Minandri, F., Imperi, F., Visca, P. (2014). Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(9), 5572-5575 [10.1128/AAC.03154-14].

Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa

Imperi F;VISCA, PAOLO
2014-01-01

Abstract

Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon.
2014
Frangipani, E., Bonchi, C., Minandri, F., Imperi, F., Visca, P. (2014). Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(9), 5572-5575 [10.1128/AAC.03154-14].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/138626
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