Benvenuti nell'Anagrafe della Ricerca d'Ateneo
La valutazione delle attività di ricerca che si svolgono nelle università ha assunto un'importanza rilevante sia per l'intero sistema universitario sia all'interno di ogni singolo ateneo. Roma Tre si è quindi dotata di idonei strumenti informativi in grado di supportare al meglio le azioni di monitoraggio e di valutazione delle attività di ricerca svolte nei propri dipartimentied ha realizzato una Anagrafe della Ricerca di Ateneo.
EnglishGallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon
Frangipani E, Bonchi C, Minandri F, Imperi F, & Visca P (2014). Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(9), 5572-5575 [10.1128/AAC.03154-14].
| Titolo: | Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa | |
| Autori: | ||
| Data di pubblicazione: | 2014 | |
| Rivista: | ||
| Citazione: | Frangipani E, Bonchi C, Minandri F, Imperi F, & Visca P (2014). Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(9), 5572-5575 [10.1128/AAC.03154-14]. | |
| Abstract: | Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon | |
| Handle: | http://hdl.handle.net/11590/139008 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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