Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon
Frangipani E, Bonchi C, Minandri F, Imperi F, & Visca P (2014). Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(9), 5572-5575.
Titolo: | Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa |
Autori: | |
Data di pubblicazione: | 2014 |
Rivista: | |
Citazione: | Frangipani E, Bonchi C, Minandri F, Imperi F, & Visca P (2014). Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(9), 5572-5575. |
Abstract: | Gallium (Ga) is an iron mimetic that has successfully been repurposed for antibacterial chemotherapy. To improve the antibacterial potency of Ga on Pseudomonas aeruginosa, the effect of complexation with a variety of siderophores and synthetic chelators was tested. Ga complexed with the pyochelin siderophore (at a 1:2 ratio) was more efficient than Ga(NO3)3 in inhibiting P. aeruginosa growth, and its activity was dependent on increased Ga entrance into the cell through the pyochelin translocon |
Handle: | http://hdl.handle.net/11590/139008 |
Appare nelle tipologie: | 1.1 Articolo in rivista |