Benvenuti nell'Anagrafe della Ricerca d'Ateneo
La valutazione delle attività di ricerca che si svolgono nelle università ha assunto un'importanza rilevante sia per l'intero sistema universitario sia all'interno di ogni singolo ateneo. Roma Tre si è quindi dotata di idonei strumenti informativi in grado di supportare al meglio le azioni di monitoraggio e di valutazione delle attività di ricerca svolte nei propri dipartimentied ha realizzato una Anagrafe della Ricerca di Ateneo.
EnglishElectrochemically induced cyclization of bromoamides to beta-lactams has been achieved in room-temperature ionic liquids (RTILs). The use of volatile, organic solvents (VOCs) and of supporting electrolytes may be avoided. Proton exchange reaction between amide substrates and suitable electrogenerated bases gives rise to a C-4 carbanion which undergoes cyclization to beta-lactam via intramolecular nucleophilic substitution (C-3-C-4 bond formation). beta-Lactams have been isolated in good to elevated yields. The "non innocent" nature of the RTILs (imidazolium-based salts) is considered. Proton exchange reaction between N-dialkylimidazolium cation and ECB yielding N-heterocyclic carbene is discussed
SOTGIU G, I. CHIAROTTO, M. FEROCI, M. ORSINI, L. ROSSI, & A. INESI (2008). An electrochemical alternative strategy to the synthesis of b-lactams. Part 3 [1]. Room-temperature ionic liquids (RTILs) vs volatile organic solvents (VOCs). ELECTROCHIMICA ACTA, 53(27), 7852-7858 [10.1016/j.electacta.2008.05.054].
| Titolo: | An electrochemical alternative strategy to the synthesis of b-lactams. Part 3 [1]. Room-temperature ionic liquids (RTILs) vs volatile organic solvents (VOCs) | |
| Autori: | ||
| Data di pubblicazione: | 2008 | |
| Rivista: | ||
| Citazione: | SOTGIU G, I. CHIAROTTO, M. FEROCI, M. ORSINI, L. ROSSI, & A. INESI (2008). An electrochemical alternative strategy to the synthesis of b-lactams. Part 3 [1]. Room-temperature ionic liquids (RTILs) vs volatile organic solvents (VOCs). ELECTROCHIMICA ACTA, 53(27), 7852-7858 [10.1016/j.electacta.2008.05.054]. | |
| Abstract: | Electrochemically induced cyclization of bromoamides to beta-lactams has been achieved in room-temperature ionic liquids (RTILs). The use of volatile, organic solvents (VOCs) and of supporting electrolytes may be avoided. Proton exchange reaction between amide substrates and suitable electrogenerated bases gives rise to a C-4 carbanion which undergoes cyclization to beta-lactam via intramolecular nucleophilic substitution (C-3-C-4 bond formation). beta-Lactams have been isolated in good to elevated yields. The "non innocent" nature of the RTILs (imidazolium-based salts) is considered. Proton exchange reaction between N-dialkylimidazolium cation and ECB yielding N-heterocyclic carbene is discussed | |
| Handle: | http://hdl.handle.net/11590/141459 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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