PEP and aldolase mimicry is the key for a direct organocatalytic entry to precursors of ulosonic acids, biomolecules of enormous importance in biology, chemistry and medicine; in the key aldol reaction the dimethylacetal of pyruvic aldehyde is used as phosphoenolpyruvate (PEP) equivalent and the amino acid proline functions as an organocatalyst, imitating the enzyme
Enders, D., Gasperi, T. (2007). Proline organocatalysis as a new tool for the asymmetric synthesis of ulosonic acid precursors. CHEMICAL COMMUNICATIONS(1), 88-90 [10.1039/b611265j].
Proline organocatalysis as a new tool for the asymmetric synthesis of ulosonic acid precursors
GASPERI, TECLA
2007-01-01
Abstract
PEP and aldolase mimicry is the key for a direct organocatalytic entry to precursors of ulosonic acids, biomolecules of enormous importance in biology, chemistry and medicine; in the key aldol reaction the dimethylacetal of pyruvic aldehyde is used as phosphoenolpyruvate (PEP) equivalent and the amino acid proline functions as an organocatalyst, imitating the enzymeFile in questo prodotto:
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