Novel potentially bioactive spiroaziridine-oxindoles have been prepared by treatment of easily accessible 3-ylideneoxindoles with N-{[(4-nitrophenyl)sulfonyl]oxy}carbamate (NsONHCO2Et) in the presence of CaO. These compounds gave new 3-(aminoalkyl)oxindole derivatives through easy and regioselective reductive aziridine ring-opening reactions.
AMMETTO I, GASPERI T, LORETO M.A, MIGLIORINI A, PALMARELLI F, & TARDELLA P.A (2009). Synthesis of Functionalized Spiroaziridine-oxindoles from 3-Ylideneoxindoles: An Easy Route to 3-(Aminoalkyl)oxindoles. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 6189-6197 [10.1002/ejoc.200900891].
Synthesis of Functionalized Spiroaziridine-oxindoles from 3-Ylideneoxindoles: An Easy Route to 3-(Aminoalkyl)oxindoles
GASPERI, TECLA;
2009
Abstract
Novel potentially bioactive spiroaziridine-oxindoles have been prepared by treatment of easily accessible 3-ylideneoxindoles with N-{[(4-nitrophenyl)sulfonyl]oxy}carbamate (NsONHCO2Et) in the presence of CaO. These compounds gave new 3-(aminoalkyl)oxindole derivatives through easy and regioselective reductive aziridine ring-opening reactions.File in questo prodotto:
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