The reaction of (α-trimethylsilanylmethyl)cyclohexylidene esters with NsONHCO2Et and CaO produces the N-(ethoxycarbonyl)spiroaziridines which, after ring-opening, gives the corresponding β,β-disubstituted β-amino ester derivatives. The stereochemical outcome of the reaction is influenced by substituents on the cyclohexyl group
Gasperi, T., LORETO M., A., Tardella, P.A. (2003). Synthesis of β,β-branched β-amino ester derivatives through spiroaziridination of (α-trimethylsilanylmethyl)cyclohexylidene esters. TETRAHEDRON LETTERS, 44, 8467-8470 [10.1016/j.tetlet.2003.09.093].
Synthesis of β,β-branched β-amino ester derivatives through spiroaziridination of (α-trimethylsilanylmethyl)cyclohexylidene esters
GASPERI, TECLA;
2003-01-01
Abstract
The reaction of (α-trimethylsilanylmethyl)cyclohexylidene esters with NsONHCO2Et and CaO produces the N-(ethoxycarbonyl)spiroaziridines which, after ring-opening, gives the corresponding β,β-disubstituted β-amino ester derivatives. The stereochemical outcome of the reaction is influenced by substituents on the cyclohexyl groupFile in questo prodotto:
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