Biofilm-associated infections caused by Acinetobacter baumannii are extremely recalcitrant to antibiotic treatment. We report that A. baumannii develops a mature biofilm when grown in complement-free human serum (HS). We demonstrate that 16 μM gallium nitrate (GaN) drastically reduces A. baumannii growth and biofilm formation in HS, whereas 64 μM GaN causes massive disruption of preformed A. baumannii biofilm. These findings pave the way to the repurposing of GaN as an antibiofilm agent for A. baumannii.
Runci, F., Bonchi, C., Frangipani, E., Visaggio, D., Visca, P. (2017). Acinetobacter baumannii biofilm formation in Human serum and disruption by gallium. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61(1) [10.1128/AAC.01563-16].
Acinetobacter baumannii biofilm formation in Human serum and disruption by gallium
RUNCI, FEDERICA;BONCHI, CARLO;FRANGIPANI, EMANUELA;VISAGGIO, DANIELA;VISCA, PAOLO
2017-01-01
Abstract
Biofilm-associated infections caused by Acinetobacter baumannii are extremely recalcitrant to antibiotic treatment. We report that A. baumannii develops a mature biofilm when grown in complement-free human serum (HS). We demonstrate that 16 μM gallium nitrate (GaN) drastically reduces A. baumannii growth and biofilm formation in HS, whereas 64 μM GaN causes massive disruption of preformed A. baumannii biofilm. These findings pave the way to the repurposing of GaN as an antibiofilm agent for A. baumannii.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
