There is epidemiological evidence for increased non-cancer mortality, primarily due to circulatory diseases after radiation exposure above 0.5 Sv. We evaluated the effects of chronic low-dose rate versus acute exposures in a murine model of spontaneous atherogenesis. Female ApoE-/-mice (60 days) were chronically irradiated for 300 days with gamma rays at two different dose rates (1 mGy/day; 20 mGy/day), with total accumulated doses of 0.3 or 6 Gy. For comparison, age-matched ApoE-/-females were acutely exposed to the same doses and sacrificed 300 days post-irradiation. Mice acutely exposed to 0.3 or 6 Gy showed increased atherogenesis compared to age-matched controls, and this effect was persistent. When the same doses were delivered at low dose rate over 300 days, we again observed a significant impact on global development of atherosclerosis, although at 0.3 Gy effects were limited to the descending thoracic aorta. Our data suggest that a moderate dose of 0.3 Gy can have persistent detrimental effects on the cardiovascular system, and that a high dose of 6 Gy poses high risks at both high and low dose rates. Our results were clearly nonlinear with dose, suggesting that lower doses may be more damaging than predicted by a linear dose response.

Mancuso, M., Pasquali, E., Braga-Tanaka, I., Tanaka, S., Pannicelli, A., Giardullo, P., et al. (2015). Acceleration of atherogenesis in ApoE-/-mice exposed to acute or low-dose-rate ionizing radiation. ONCOTARGET, 6(31), 31263-31271 [10.18632/oncotarget.5075].

Acceleration of atherogenesis in ApoE-/-mice exposed to acute or low-dose-rate ionizing radiation

Giardullo, Paola;
2015-01-01

Abstract

There is epidemiological evidence for increased non-cancer mortality, primarily due to circulatory diseases after radiation exposure above 0.5 Sv. We evaluated the effects of chronic low-dose rate versus acute exposures in a murine model of spontaneous atherogenesis. Female ApoE-/-mice (60 days) were chronically irradiated for 300 days with gamma rays at two different dose rates (1 mGy/day; 20 mGy/day), with total accumulated doses of 0.3 or 6 Gy. For comparison, age-matched ApoE-/-females were acutely exposed to the same doses and sacrificed 300 days post-irradiation. Mice acutely exposed to 0.3 or 6 Gy showed increased atherogenesis compared to age-matched controls, and this effect was persistent. When the same doses were delivered at low dose rate over 300 days, we again observed a significant impact on global development of atherosclerosis, although at 0.3 Gy effects were limited to the descending thoracic aorta. Our data suggest that a moderate dose of 0.3 Gy can have persistent detrimental effects on the cardiovascular system, and that a high dose of 6 Gy poses high risks at both high and low dose rates. Our results were clearly nonlinear with dose, suggesting that lower doses may be more damaging than predicted by a linear dose response.
2015
Mancuso, M., Pasquali, E., Braga-Tanaka, I., Tanaka, S., Pannicelli, A., Giardullo, P., et al. (2015). Acceleration of atherogenesis in ApoE-/-mice exposed to acute or low-dose-rate ionizing radiation. ONCOTARGET, 6(31), 31263-31271 [10.18632/oncotarget.5075].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/330452
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