The mevalonate (MVA)/cholesterol pathway is crucial for central nervous system (CNS) development and function and consequently, any dysfunction of this fundamental metabolic pathway is likely to provoke pathologic changes in the brain. Mutations in genes directly involved in MVA/cholesterol metabolism cause a range of diseases, many of which present neurologic and psychiatric symptoms. This raises the question whether other diseases presenting similar symptoms are related albeit indirectly to the MVA/cholesterol pathway. Here, we summarized the current literature suggesting links between MVA/cholesterol dysregulation and specific diseases, namely autism spectrum disorder and Rett syndrome.

Segatto, M., Tonini, C., Pfrieger, F.W., Trezza, V., & Pallottini, V. (2019). Loss of mevalonate/cholesterol homeostasis in the brain: A focus on autism spectrum disorder and rett syndrome. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(13), 3317 [10.3390/ijms20133317].

Loss of mevalonate/cholesterol homeostasis in the brain: A focus on autism spectrum disorder and rett syndrome

Segatto M.
Membro del Collaboration Group
;
Tonini C.
Membro del Collaboration Group
;
Trezza V.
Membro del Collaboration Group
;
Pallottini V.
Funding Acquisition
2019

Abstract

The mevalonate (MVA)/cholesterol pathway is crucial for central nervous system (CNS) development and function and consequently, any dysfunction of this fundamental metabolic pathway is likely to provoke pathologic changes in the brain. Mutations in genes directly involved in MVA/cholesterol metabolism cause a range of diseases, many of which present neurologic and psychiatric symptoms. This raises the question whether other diseases presenting similar symptoms are related albeit indirectly to the MVA/cholesterol pathway. Here, we summarized the current literature suggesting links between MVA/cholesterol dysregulation and specific diseases, namely autism spectrum disorder and Rett syndrome.
Segatto, M., Tonini, C., Pfrieger, F.W., Trezza, V., & Pallottini, V. (2019). Loss of mevalonate/cholesterol homeostasis in the brain: A focus on autism spectrum disorder and rett syndrome. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(13), 3317 [10.3390/ijms20133317].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11590/354584
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