Benvenuti nell'Anagrafe della Ricerca d'Ateneo
La valutazione delle attività di ricerca che si svolgono nelle università ha assunto un'importanza rilevante sia per l'intero sistema universitario sia all'interno di ogni singolo ateneo. Roma Tre si è quindi dotata di idonei strumenti informativi in grado di supportare al meglio le azioni di monitoraggio e di valutazione delle attività di ricerca svolte nei propri dipartimentied ha realizzato una Anagrafe della Ricerca di Ateneo.
EnglishDysfunctional mitochondria have severe consequences on cell functions including Reactive Oxygen Specie (ROS) generation, alteration of mitochondrial signaling, Ca2+ buffering, and activation of apoptotic pathway. These dysfunctions are closely linked with degenerative diseases including neurodegeneration. The discovery of neuroglobin (NGB) as an endogenous neuroprotective protein, which effects seem to depend on its mitochondrial localization, could drive new therapeutic strategies against aged-related neurodegenerative diseases. Indeed, high levels of NGB are active against several brain injuries, including neurodegeneration, hypoxia, ischemia, toxicity, and nutrient deprivation opening a new scenario in the comprehension of the relationship between neural pathologies and mitochondrial homeostasis. In this review, we provide the current understanding of the role of mitochondria in neurodegeneration and discuss structural and functional connection between NGB and mitochondria with the purpose of defining a novel mitochondrial-based neuroprotective mechanism(s).
Fiocchetti, M., Cracco, P., Montalesi, E., Solar Fernandez, V., Stuart, J.A., & Marino, M. (2021). Neuroglobin and mitochondria: The impact on neurodegenerative diseases. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 701, 108823 [10.1016/j.abb.2021.108823].
| Titolo: | Neuroglobin and mitochondria: The impact on neurodegenerative diseases | |
| Autori: | ||
| Data di pubblicazione: | 2021 | |
| Rivista: | ||
| Citazione: | Fiocchetti, M., Cracco, P., Montalesi, E., Solar Fernandez, V., Stuart, J.A., & Marino, M. (2021). Neuroglobin and mitochondria: The impact on neurodegenerative diseases. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 701, 108823 [10.1016/j.abb.2021.108823]. | |
| Abstract: | Dysfunctional mitochondria have severe consequences on cell functions including Reactive Oxygen Specie (ROS) generation, alteration of mitochondrial signaling, Ca2+ buffering, and activation of apoptotic pathway. These dysfunctions are closely linked with degenerative diseases including neurodegeneration. The discovery of neuroglobin (NGB) as an endogenous neuroprotective protein, which effects seem to depend on its mitochondrial localization, could drive new therapeutic strategies against aged-related neurodegenerative diseases. Indeed, high levels of NGB are active against several brain injuries, including neurodegeneration, hypoxia, ischemia, toxicity, and nutrient deprivation opening a new scenario in the comprehension of the relationship between neural pathologies and mitochondrial homeostasis. In this review, we provide the current understanding of the role of mitochondria in neurodegeneration and discuss structural and functional connection between NGB and mitochondria with the purpose of defining a novel mitochondrial-based neuroprotective mechanism(s). | |
| Handle: | http://hdl.handle.net/11590/385974 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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