In this work we evaluated plasmacytoid (pDC) and myeloid dendritic (mDC) cells activation before and during anti-HCV treatment in HCV+/HIV+ individuals.HCV+/HIV+ patients received Peg-IFN-α2b subcutaneously for 28. days, followed by oral weight-based ribavirin. DCs activation was evaluated by flow cytometry.Baseline pDC CD80 and CD86 expression was correlated with HIV, but not with HCV viral load. A transient decrease of HIV RNA was found not associated with DC activation. When patients were grouped according to early/sustained virological response (EVR/SVR) to anti-HCV treatment, baseline pDC CD80 and CD86 expression was higher in non-EVR and non-SVR compared to EVR and SVR. Moreover, in responder patients CD80 and CD86 were upregulated by IFN-α. Our data suggest a correlation between DCs activation and response to therapy. These findings could be helpful to better understand the mediators of IFN-α action in HCV+/HIV+ patients and to explore possible exploitation of this knowledge to improve therapeutic response. © 2010 Elsevier Inc.

Sacchi, A., Agrati, C., D'Offizi, G., Vlassi, C., Rozera, G., Abbate, I., et al. (2011). The basal activation state of DC subsets correlates with anti-HCV treatment outcome in HCV/HIV co-infected patients. CLINICAL IMMUNOLOGY, 138(2), 178-186 [10.1016/j.clim.2010.11.001].

The basal activation state of DC subsets correlates with anti-HCV treatment outcome in HCV/HIV co-infected patients

Sacchi A.;
2011

Abstract

In this work we evaluated plasmacytoid (pDC) and myeloid dendritic (mDC) cells activation before and during anti-HCV treatment in HCV+/HIV+ individuals.HCV+/HIV+ patients received Peg-IFN-α2b subcutaneously for 28. days, followed by oral weight-based ribavirin. DCs activation was evaluated by flow cytometry.Baseline pDC CD80 and CD86 expression was correlated with HIV, but not with HCV viral load. A transient decrease of HIV RNA was found not associated with DC activation. When patients were grouped according to early/sustained virological response (EVR/SVR) to anti-HCV treatment, baseline pDC CD80 and CD86 expression was higher in non-EVR and non-SVR compared to EVR and SVR. Moreover, in responder patients CD80 and CD86 were upregulated by IFN-α. Our data suggest a correlation between DCs activation and response to therapy. These findings could be helpful to better understand the mediators of IFN-α action in HCV+/HIV+ patients and to explore possible exploitation of this knowledge to improve therapeutic response. © 2010 Elsevier Inc.
Sacchi, A., Agrati, C., D'Offizi, G., Vlassi, C., Rozera, G., Abbate, I., et al. (2011). The basal activation state of DC subsets correlates with anti-HCV treatment outcome in HCV/HIV co-infected patients. CLINICAL IMMUNOLOGY, 138(2), 178-186 [10.1016/j.clim.2010.11.001].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11590/400090
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