We report two cases of Corona Virus Disease-19 (COVID-19) in patients with Down Syndrome (DS) and describe the identification, diagnosis, clinical course and management of the infection. Down Syndrome, which is caused by trisomy 21, is characterized by immune dysregulation, anatomical differences in the upper respiratory tract and higher rate of comorbidities. All these risk factors can contribute to more severe clinical presentations of COVID-19 in this population. It is essential to raise awareness of the clinical relevance of SARS-COV-2 infection in DS patients, as well as in other most vulnerable patients, in order to improve their management and treatment and to encourage vaccinating these individuals early, once a vaccination is available.

Vita, S., Di Bari, V., Corpolongo, A., Goletti, D., Espinosa, J., Petracca, S., et al. (2021). Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 103, 607-610 [10.1016/j.ijid.2020.11.188].

Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome

Marani A.;Pisciotta M.;Sacchi A.;
2021-01-01

Abstract

We report two cases of Corona Virus Disease-19 (COVID-19) in patients with Down Syndrome (DS) and describe the identification, diagnosis, clinical course and management of the infection. Down Syndrome, which is caused by trisomy 21, is characterized by immune dysregulation, anatomical differences in the upper respiratory tract and higher rate of comorbidities. All these risk factors can contribute to more severe clinical presentations of COVID-19 in this population. It is essential to raise awareness of the clinical relevance of SARS-COV-2 infection in DS patients, as well as in other most vulnerable patients, in order to improve their management and treatment and to encourage vaccinating these individuals early, once a vaccination is available.
Vita, S., Di Bari, V., Corpolongo, A., Goletti, D., Espinosa, J., Petracca, S., et al. (2021). Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome. INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 103, 607-610 [10.1016/j.ijid.2020.11.188].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/400094
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