The aim of the present study was to explain the observed anergy of Vγ9Vδ2 T cells from human immunodeficiency virus (HIV)-positive patients. CD3ζ expression and interferon (IFN)-γ production by Vγ9Vδ2 T cells from HIV-positive and HIV-negative subjects were analyzed. We demonstrated that Vγ9Vδ2 T cells from HIV-infected patients expressed a lower level of CD3ζ than did Vγ9Vδ2 T cells from healthy donors. A direct correlation was found between CD3ζ expression and IFN-γ production capability by Vγ9Vδ2 T cells. However, activation of protein kinase C by phorbol myristate acetate is able to restore CD3ζ expression and IFN-γ production. Our findings may contribute to clarification of the molecular mechanisms of Vγ9Vδ2 T cell anergy found in HIV-positive patients. © 2008 by the Infectious Diseases Society of America. All rights reserved.

Sacchi, A., Tempestilli, M., Turchi, F., Agrati, C., Casetti, R., Cimini, E., et al. (2009). CD3ζ down-modulation may explain Vγ9Vδ2 T lymphocyte anergy in HIV-infected patients. THE JOURNAL OF INFECTIOUS DISEASES, 199(3), 432-436 [10.1086/596047].

CD3ζ down-modulation may explain Vγ9Vδ2 T lymphocyte anergy in HIV-infected patients

Sacchi A.;Tempestilli M.;Cimini E.;Gioia C.;Martini F.
2009

Abstract

The aim of the present study was to explain the observed anergy of Vγ9Vδ2 T cells from human immunodeficiency virus (HIV)-positive patients. CD3ζ expression and interferon (IFN)-γ production by Vγ9Vδ2 T cells from HIV-positive and HIV-negative subjects were analyzed. We demonstrated that Vγ9Vδ2 T cells from HIV-infected patients expressed a lower level of CD3ζ than did Vγ9Vδ2 T cells from healthy donors. A direct correlation was found between CD3ζ expression and IFN-γ production capability by Vγ9Vδ2 T cells. However, activation of protein kinase C by phorbol myristate acetate is able to restore CD3ζ expression and IFN-γ production. Our findings may contribute to clarification of the molecular mechanisms of Vγ9Vδ2 T cell anergy found in HIV-positive patients. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Sacchi, A., Tempestilli, M., Turchi, F., Agrati, C., Casetti, R., Cimini, E., et al. (2009). CD3ζ down-modulation may explain Vγ9Vδ2 T lymphocyte anergy in HIV-infected patients. THE JOURNAL OF INFECTIOUS DISEASES, 199(3), 432-436 [10.1086/596047].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11590/400169
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 9
  • ???jsp.display-item.citation.isi??? ND
social impact