Dendritic cells and γδ T-lymphocytes play a crucial role in the early response to microbial infections. Since both dendritic cells and γδ T-lymphocytes may be activated by specific microbial products, we analyzed their interplay in the presence of such respective ligands: lipopolysaccharide and isopentenyl-pyrophosphate. Activated γδ T-cells increased the maturational state of dendritic cells induced by lipopolysaccharide, increasing the expression of co-stimulatory and MHC class I and II molecules. IL-12 production by dendritic cells was strongly amplified in the presence of activated γδ T-cells and the Th1 polarization of naïve CD4+ T-lymphocytes was significantly increased. On the other hand, dendritic cells enhanced γδ T-cell functions induced by isopentenyl-pyrophosphate and promote their IL-2 independent proliferation through CD86 contact. Altogether, dendritic cells and γδ T-cells exert a complementary function promoting an optimal immune response to non peptidic microbial antigens. © 2005 Springer Science+Business Media, Inc.

Martino, A., Casetti, R., D'Alessandri, A., Sacchi, A., & Poccia, F. (2005). Complementary function of γδ T-lymphocytes and dendritic cells in the response to isopentenyl-pyrophosphate and lipopolysaccharide antigens. JOURNAL OF CLINICAL IMMUNOLOGY, 25(3), 230-237 [10.1007/s10875-005-4080-8].

Complementary function of γδ T-lymphocytes and dendritic cells in the response to isopentenyl-pyrophosphate and lipopolysaccharide antigens

Martino A.;Sacchi A.;Poccia F.
2005

Abstract

Dendritic cells and γδ T-lymphocytes play a crucial role in the early response to microbial infections. Since both dendritic cells and γδ T-lymphocytes may be activated by specific microbial products, we analyzed their interplay in the presence of such respective ligands: lipopolysaccharide and isopentenyl-pyrophosphate. Activated γδ T-cells increased the maturational state of dendritic cells induced by lipopolysaccharide, increasing the expression of co-stimulatory and MHC class I and II molecules. IL-12 production by dendritic cells was strongly amplified in the presence of activated γδ T-cells and the Th1 polarization of naïve CD4+ T-lymphocytes was significantly increased. On the other hand, dendritic cells enhanced γδ T-cell functions induced by isopentenyl-pyrophosphate and promote their IL-2 independent proliferation through CD86 contact. Altogether, dendritic cells and γδ T-cells exert a complementary function promoting an optimal immune response to non peptidic microbial antigens. © 2005 Springer Science+Business Media, Inc.
Martino, A., Casetti, R., D'Alessandri, A., Sacchi, A., & Poccia, F. (2005). Complementary function of γδ T-lymphocytes and dendritic cells in the response to isopentenyl-pyrophosphate and lipopolysaccharide antigens. JOURNAL OF CLINICAL IMMUNOLOGY, 25(3), 230-237 [10.1007/s10875-005-4080-8].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11590/400177
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