HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34+ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34+ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34+ HPCs to produce an adequate number of DCs.
Bordoni, V., Bibas, M., Viola, D., Sacchi, A., Agrati, C., Castelli, G., et al. (2013). Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 64(4), 342-344 [10.1097/QAI.0b013e3182a40ff7].
Titolo: | Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells | |
Autori: | ||
Data di pubblicazione: | 2013 | |
Rivista: | ||
Citazione: | Bordoni, V., Bibas, M., Viola, D., Sacchi, A., Agrati, C., Castelli, G., et al. (2013). Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 64(4), 342-344 [10.1097/QAI.0b013e3182a40ff7]. | |
Handle: | http://hdl.handle.net/11590/400189 | |
Appare nelle tipologie: | 1.1 Articolo in rivista |