HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34+ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34+ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34+ HPCs to produce an adequate number of DCs.
Bordoni, V., Bibas, M., Viola, D., Sacchi, A., Agrati, C., Castelli, G., et al. (2013). Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 64(4), 342-344 [10.1097/QAI.0b013e3182a40ff7].
Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells
Sacchi A.;Martini F.
2013-01-01
Abstract
HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34+ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34+ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34+ HPCs to produce an adequate number of DCs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
