99mTc-d,l-hexamethylpropylene amine oxime (99mTc-HMPAO) retention in brain is proportional to cerebral blood flow and related to both the local hemodynamic state and to the cellular content of reduced glutathione. Alterations of the regional distribution of 99mTc-HMPAO retention, with discrepant results, have been reported at functional brain imaging of unipolar depression. Since mitochondrial involvement has been reported in depressed patients, the aim of the study was to explore whether the 99mTc-HMPAO retention at single-photon emission computed tomography in depressed patients may relate to different levels of mitochondrial function.

Gardner, A., Salmaso, D., Nardo, D., Micucci, F., Nobili, F., Sanchez-Crespo, A., et al. (2008). Mitochondrial function is related to alterations at brain SPECT in depressed patients. CNS SPECTRUMS, 13(9), 805-814 [10.1017/s1092852900013936].

Mitochondrial function is related to alterations at brain SPECT in depressed patients

Nardo, Davide;
2008

Abstract

99mTc-d,l-hexamethylpropylene amine oxime (99mTc-HMPAO) retention in brain is proportional to cerebral blood flow and related to both the local hemodynamic state and to the cellular content of reduced glutathione. Alterations of the regional distribution of 99mTc-HMPAO retention, with discrepant results, have been reported at functional brain imaging of unipolar depression. Since mitochondrial involvement has been reported in depressed patients, the aim of the study was to explore whether the 99mTc-HMPAO retention at single-photon emission computed tomography in depressed patients may relate to different levels of mitochondrial function.
Gardner, A., Salmaso, D., Nardo, D., Micucci, F., Nobili, F., Sanchez-Crespo, A., et al. (2008). Mitochondrial function is related to alterations at brain SPECT in depressed patients. CNS SPECTRUMS, 13(9), 805-814 [10.1017/s1092852900013936].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/418937
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 17
social impact