Although centrosome abnormalities are frequent in cancer, the mechanisms responsible for their accumulation are poorly understood. Here we comment on our recent publication identifying a new type of selective autophagy, named doryphagy, which preserves centrosome organization through targeting Centriolar Satellites (CS). Thus, doryphagy prevents inaccurate mitosis and genomic instability.
Cianfanelli, V., Cecconi, F. (2020). Doryphagy: when selective autophagy safeguards centrosome integrity. MOLECULAR & CELLULAR ONCOLOGY, 7(2), 1719021 [10.1080/23723556.2020.1719021].
Doryphagy: when selective autophagy safeguards centrosome integrity
Cianfanelli, Valentina
;Cecconi, Francesco
2020-01-01
Abstract
Although centrosome abnormalities are frequent in cancer, the mechanisms responsible for their accumulation are poorly understood. Here we comment on our recent publication identifying a new type of selective autophagy, named doryphagy, which preserves centrosome organization through targeting Centriolar Satellites (CS). Thus, doryphagy prevents inaccurate mitosis and genomic instability.File in questo prodotto:
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