: Nitric oxide (NO) is an essential signaling molecule present in most living organisms including bacteria, fungi, plants, and animals. NO participates in a wide range of biological processes including vasomotor tone, neurotransmission, and immune response. However, NO is highly reactive and can give rise to reactive nitrogen and oxygen species that, in turn, can modify a broad range of biomolecules. Much evidence supports the critical role of NO in the virulence and replication of viruses, bacteria, protozoan, metazoan, and fungi, thus representing a general mechanism of host defense. However, pathogens have developed different mechanisms to elude the host NO and to protect themselves against oxidative and nitrosative stress. Here, the strategies evolved by viruses, bacteria, protozoan, metazoan, and fungi to escape from the NO-based host defense are overviewed.

De Simone, G., di Masi, A., Ascenzi, P. (2022). Strategies of Pathogens to Escape from NO-Based Host Defense. ANTIOXIDANTS, 11(11), 2176 [10.3390/antiox11112176].

Strategies of Pathogens to Escape from NO-Based Host Defense

De Simone, Giovanna
;
di Masi, Alessandra;Ascenzi, Paolo
2022-01-01

Abstract

: Nitric oxide (NO) is an essential signaling molecule present in most living organisms including bacteria, fungi, plants, and animals. NO participates in a wide range of biological processes including vasomotor tone, neurotransmission, and immune response. However, NO is highly reactive and can give rise to reactive nitrogen and oxygen species that, in turn, can modify a broad range of biomolecules. Much evidence supports the critical role of NO in the virulence and replication of viruses, bacteria, protozoan, metazoan, and fungi, thus representing a general mechanism of host defense. However, pathogens have developed different mechanisms to elude the host NO and to protect themselves against oxidative and nitrosative stress. Here, the strategies evolved by viruses, bacteria, protozoan, metazoan, and fungi to escape from the NO-based host defense are overviewed.
2022
De Simone, G., di Masi, A., Ascenzi, P. (2022). Strategies of Pathogens to Escape from NO-Based Host Defense. ANTIOXIDANTS, 11(11), 2176 [10.3390/antiox11112176].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/426468
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