The vulnerability of humankind to SARS-CoV-2 in the absence of a pre-existing immunity, the unpredictability of the infection outcome, and the high transmissibility, broad tissue tropism, and ability to exploit and subvert the immune response pose a major challenge and are likely perpetuating the COVID-19 pandemic. Nevertheless, this peculiar infectious scenario provides researchers with a unique opportunity for studying, with the latest immunological techniques and understandings, the immune response in SARS-CoV-2 naive versus recovered subjects as well as in SARS-CoV-2 vaccinees. Interestingly, the current understanding of COVID-19 indicates that the combined action of innate immune cells, cytokines, and chemokines fine-tunes the outcome of SARS-CoV-2 infection and the related immunopathogenesis. Indeed, the emerging picture clearly shows that the excessive inflammatory response against this virus is among the main causes of disease severity in COVID-19 patients. In this review, the innate immune response to SARS-CoV-2 infection is described not only in light of its capacity to influence the adaptive immune response towards a protective phenotype but also with the intent to point out the multiple strategies exploited by SARS-CoV-2 to antagonize host antiviral response and, finally, to outline inborn errors predisposing individuals to COVID-19 disease severity.

Ricci, D., Etna, M.P., Rizzo, F., Sandini, S., Severa, M., Coccia, E.M. (2021). Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(13) [10.3390/ijms22137017].

Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators

Ricci, Daniela;Rizzo, Fabiana;Coccia, Eliana Marina
2021-01-01

Abstract

The vulnerability of humankind to SARS-CoV-2 in the absence of a pre-existing immunity, the unpredictability of the infection outcome, and the high transmissibility, broad tissue tropism, and ability to exploit and subvert the immune response pose a major challenge and are likely perpetuating the COVID-19 pandemic. Nevertheless, this peculiar infectious scenario provides researchers with a unique opportunity for studying, with the latest immunological techniques and understandings, the immune response in SARS-CoV-2 naive versus recovered subjects as well as in SARS-CoV-2 vaccinees. Interestingly, the current understanding of COVID-19 indicates that the combined action of innate immune cells, cytokines, and chemokines fine-tunes the outcome of SARS-CoV-2 infection and the related immunopathogenesis. Indeed, the emerging picture clearly shows that the excessive inflammatory response against this virus is among the main causes of disease severity in COVID-19 patients. In this review, the innate immune response to SARS-CoV-2 infection is described not only in light of its capacity to influence the adaptive immune response towards a protective phenotype but also with the intent to point out the multiple strategies exploited by SARS-CoV-2 to antagonize host antiviral response and, finally, to outline inborn errors predisposing individuals to COVID-19 disease severity.
2021
Ricci, D., Etna, M.P., Rizzo, F., Sandini, S., Severa, M., Coccia, E.M. (2021). Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(13) [10.3390/ijms22137017].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/475909
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