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Pentadecylidenemalonate 1b, a simplified analogue of anacardic acid, was identified as the first mixed activator/inhibitor of histone acetyltransferases (HATs). It potentiates PCAF HAT activity while inhibiting those of p300/CBP and recombinant CBP. The remarkable apoptotic effect together with the ability to selectively acetylate histone versus non-histone substrates appoint 1b as a lead for the development of anticancer drugs. © 2008 Elsevier Ltd. All rights reserved.

Gianluca, S., Sabrina, C., Caterina, V., Rotili, D., Angela, N., Marco, M., et al. (2008). Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(9), 2788-2792 [10.1016/j.bmcl.2008.04.017].

Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases

ROTILI, Dante;
2008-01-01

Abstract

Pentadecylidenemalonate 1b, a simplified analogue of anacardic acid, was identified as the first mixed activator/inhibitor of histone acetyltransferases (HATs). It potentiates PCAF HAT activity while inhibiting those of p300/CBP and recombinant CBP. The remarkable apoptotic effect together with the ability to selectively acetylate histone versus non-histone substrates appoint 1b as a lead for the development of anticancer drugs. © 2008 Elsevier Ltd. All rights reserved.
2008
Gianluca, S., Sabrina, C., Caterina, V., Rotili, D., Angela, N., Marco, M., et al. (2008). Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(9), 2788-2792 [10.1016/j.bmcl.2008.04.017].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/493050
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