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(Chemical Equation Presented) Sirtuins are deacetylase proteins that regulate transcription, genome maintenance, longevity, and metabolism. Eight compounds were identified as a novel class of sirtuin inhibitors, with 5, 7, and 9 being the most effective as SIRT1-selective inhibitors. In U937 cells 5 induced apoptosis and displayed antiproliferative effects in Raji, DLD1, and HeLa cancer cells, suggesting potential utility in cancer treatment. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

Rotili, D., Tarantino, D., Vincenzo, C., Ester, L., Sarah, M., Giorgia, B., et al. (2010). Identification of Tri- and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors. CHEMMEDCHEM, 5(5), 674-677 [10.1002/cmdc.201000030].

Identification of Tri- and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors

ROTILI, Dante;
2010-01-01

Abstract

(Chemical Equation Presented) Sirtuins are deacetylase proteins that regulate transcription, genome maintenance, longevity, and metabolism. Eight compounds were identified as a novel class of sirtuin inhibitors, with 5, 7, and 9 being the most effective as SIRT1-selective inhibitors. In U937 cells 5 induced apoptosis and displayed antiproliferative effects in Raji, DLD1, and HeLa cancer cells, suggesting potential utility in cancer treatment. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
2010
Rotili, D., Tarantino, D., Vincenzo, C., Ester, L., Sarah, M., Giorgia, B., et al. (2010). Identification of Tri- and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors. CHEMMEDCHEM, 5(5), 674-677 [10.1002/cmdc.201000030].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11590/493117
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