The lithium salts of 4-methoxy-derivatives of pyrimidinic bases undergo chemoselective N1-methylation or ethylation when treated with the appropriate alkylsulphate in dry dioxane. Under the same conditions, 4-unprotected pyrimidinic bases afford mixtures of N1-, O2- and N1,N3-alkylation products. This is explained in terms of HSAB principle. -
Augusto, G., Tofani, D. (2004). HSAB Driven N1-Alkylation of Uracil Derivatives. In 5th Spanish Italian Symposium on Organic Chemistry, Book of Abstracts, September 10th-13t, 2004, Santiago de Compostela, Spain (pp.p.117). Santiago de Compostela : /.
HSAB Driven N1-Alkylation of Uracil Derivatives
TOFANI, DANIELA
2004-01-01
Abstract
The lithium salts of 4-methoxy-derivatives of pyrimidinic bases undergo chemoselective N1-methylation or ethylation when treated with the appropriate alkylsulphate in dry dioxane. Under the same conditions, 4-unprotected pyrimidinic bases afford mixtures of N1-, O2- and N1,N3-alkylation products. This is explained in terms of HSAB principle. -File in questo prodotto:
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