Our data suggest that MBP interacts with astroglial cells, priming their activation, as proven by HLA class II modulation and HO-1 induction. MBP binding seems to be mediated by LRP,an endocytosis-mediating receptor. Such an interaction is followed by an increase of intracellular ROS content which, possibly, is counteracted by HO-1 induction. Many reports outlined the expression of HO-1 in multiple sclerosis and EAE, but its role in these diseases is still unclear (Chakrabarty et al. 2003), even if a growing body of evidence suggests that overexpression of HO-1 may protect tissues from immune-mediated injury either through prevention of oxidative damage or via a local immunomodulatory influence on infiltrating inflammatory cells (Kapturczak et al., 2004).
Businaro, R., Fumagalli, L., Leone, S., Lauro, G.M. (2004). RECEPTOR MACHINERY INVOLVED IN MBP-INDUCED ASTROCYTE ACTIVATIONVII International Congress of Neuroimmunology (International Society of Neuroimmunology.. In J. of Neuroimmunology. . : ..
RECEPTOR MACHINERY INVOLVED IN MBP-INDUCED ASTROCYTE ACTIVATIONVII International Congress of Neuroimmunology (International Society of Neuroimmunology.
LEONE, STEFANO;LAURO, Giuliana Maria
2004-01-01
Abstract
Our data suggest that MBP interacts with astroglial cells, priming their activation, as proven by HLA class II modulation and HO-1 induction. MBP binding seems to be mediated by LRP,an endocytosis-mediating receptor. Such an interaction is followed by an increase of intracellular ROS content which, possibly, is counteracted by HO-1 induction. Many reports outlined the expression of HO-1 in multiple sclerosis and EAE, but its role in these diseases is still unclear (Chakrabarty et al. 2003), even if a growing body of evidence suggests that overexpression of HO-1 may protect tissues from immune-mediated injury either through prevention of oxidative damage or via a local immunomodulatory influence on infiltrating inflammatory cells (Kapturczak et al., 2004).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
