The brain structure is a complex network of interconnected regions with specific topological characteristics. Since the disruption of this infrastructure has been linked to brain diseases, a key element to the quest for understanding how such diseases start and spread is to outline the degenerative pattern. In this paper, we explored this aspect using network attack simulation on the structural connectomes of 60 patients among Alzheimer's disease (AD) and mild cognitive impairment (MCI) and 30 healthy subjects. We considered different attack strategies and different metrics to evaluate and compare the induced changes between the different groups. We found out that patients and controls share common attack tolerance patterns in the peripheral connections compared to each other, and that hubs played analogous role in the tolerance impact. These results suggest that the spreading pattern of Alzheimer's disease does not target specific class of regions.

Mancini, M., De Reus, M.A., Serra, L., Bozzali, M., Van Den Heuvel, M.P., Cercignani, M., et al. (2016). Network attack simulations in Alzheimer's disease: The link between network tolerance and neurodegeneration. In Proceedings - International Symposium on Biomedical Imaging (pp.237-240). IEEE Computer Society [10.1109/ISBI.2016.7493253].

Network attack simulations in Alzheimer's disease: The link between network tolerance and neurodegeneration

MANCINI, MATTEO;CONFORTO, SILVIA
2016

Abstract

The brain structure is a complex network of interconnected regions with specific topological characteristics. Since the disruption of this infrastructure has been linked to brain diseases, a key element to the quest for understanding how such diseases start and spread is to outline the degenerative pattern. In this paper, we explored this aspect using network attack simulation on the structural connectomes of 60 patients among Alzheimer's disease (AD) and mild cognitive impairment (MCI) and 30 healthy subjects. We considered different attack strategies and different metrics to evaluate and compare the induced changes between the different groups. We found out that patients and controls share common attack tolerance patterns in the peripheral connections compared to each other, and that hubs played analogous role in the tolerance impact. These results suggest that the spreading pattern of Alzheimer's disease does not target specific class of regions.
9781479923502
Mancini, M., De Reus, M.A., Serra, L., Bozzali, M., Van Den Heuvel, M.P., Cercignani, M., et al. (2016). Network attack simulations in Alzheimer's disease: The link between network tolerance and neurodegeneration. In Proceedings - International Symposium on Biomedical Imaging (pp.237-240). IEEE Computer Society [10.1109/ISBI.2016.7493253].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11590/306989
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 7
social impact