A Terahertz protein sensing concept based on subwavelength Ge resonators is presented. Ge bowtie resonators, compatible with CMOS fabrication technology, have been designed and characterized with a resonance frequency of 0.5 THz and calculated local intensity enhancement of 10.000. Selective biofunctionalization of Ge resonators on Si wafer was achieved in one step using lipoic acid-HaloTag ligand (LA-HTL) for biofunctionalization and passivation. The results lay the foundation for future investigation of protein tertiary structure and the dynamics of protein hydration shell in response to protein conformation changes.
Bettenhausen, M., Römer, F., Witzigmann, B., Flesch, J., Kurre, R., Korneev, S., et al. (2018). Germanium Plasmon Enhanced Resonators for Label-Free Terahertz Protein Sensing. FREQUENZ, 72(3-4), 113-122 [10.1515/freq-2018-0009].
Germanium Plasmon Enhanced Resonators for Label-Free Terahertz Protein Sensing
Capellini, GiovanniWriting – Original Draft Preparation
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2018-01-01
Abstract
A Terahertz protein sensing concept based on subwavelength Ge resonators is presented. Ge bowtie resonators, compatible with CMOS fabrication technology, have been designed and characterized with a resonance frequency of 0.5 THz and calculated local intensity enhancement of 10.000. Selective biofunctionalization of Ge resonators on Si wafer was achieved in one step using lipoic acid-HaloTag ligand (LA-HTL) for biofunctionalization and passivation. The results lay the foundation for future investigation of protein tertiary structure and the dynamics of protein hydration shell in response to protein conformation changes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
