Interpretation of genotypic resistance to ritonavir-boosted saquinavir (SQV/r) is still incomplete due to limited data correlating genotypes with virological response to SQV/r. We extracted baseline VL and genotypes as well as 3-month virological outcome of HIV+ patientsenrolled in Argenta, GART, Havana and a prospective cohort (INMI), undergoing SQV/r-containing salvage regimens. Single mutations found with an association of p<0.2 respect to the 3-month VL log change from baseline (3m delta) by multiple linear regression, after adjusting by ritonavir dose, were given a weighted score according to the correlation coefficient. A technique using geneticalgorithms and fuzzy operators was tested in parallel on the whole patients set to find the best association of genotypes with 3m delta.
Prosperi, M., DI GIANBENEDETTO, S., Cingolani, A., Ruitz, L., Baxter, J.D., Clevenbergh, P., et al. (2005). Comparison of two datamining techniques for determining the role of baseline protease mutations on the virologic response to ritonavir/saquinavir-containing regimens. In 3rd European HIV drug resistance workshop (pp.1). Atene : ----.
Comparison of two datamining techniques for determining the role of baseline protease mutations on the virologic response to ritonavir/saquinavir-containing regimens
PROSPERI, MATTIA;ULIVI, Giovanni
2005-01-01
Abstract
Interpretation of genotypic resistance to ritonavir-boosted saquinavir (SQV/r) is still incomplete due to limited data correlating genotypes with virological response to SQV/r. We extracted baseline VL and genotypes as well as 3-month virological outcome of HIV+ patientsenrolled in Argenta, GART, Havana and a prospective cohort (INMI), undergoing SQV/r-containing salvage regimens. Single mutations found with an association of p<0.2 respect to the 3-month VL log change from baseline (3m delta) by multiple linear regression, after adjusting by ritonavir dose, were given a weighted score according to the correlation coefficient. A technique using geneticalgorithms and fuzzy operators was tested in parallel on the whole patients set to find the best association of genotypes with 3m delta.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
