Hydrogen sulfide (H2S) has been proposed to protect bacteria from antibiotics, pointing to H2S-producing enzymes as possible targets for the development of antibiotic adjuvants. Here, MIC assays performed with Pseudomonas aeruginosa mutants producing altered H2S levels demonstrate that H2S does not affect antibiotic resistance in this bacterium. Moreover, correlation analyses in a large collection of P. aeruginosa cystic fibrosis isolates argue against the protective role of H2S from antibiotic activity during chronic lung infection.
Caruso, L., Mellini, M., Catalano Gonzaga, O., Astegno, A., Forte, E., Di Matteo, A., et al. (2024). Hydrogen sulfide production does not affect antibiotic resistance in Pseudomonas aeruginosa. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY [10.1128/aac.00075-24].
Hydrogen sulfide production does not affect antibiotic resistance in Pseudomonas aeruginosa
Caruso, Lorenzo;Mellini, Marta;Catalano Gonzaga, Ortensia;Visca, Paolo;Imperi, Francesco;Leoni, Livia;Rampioni, Giordano
2024-01-01
Abstract
Hydrogen sulfide (H2S) has been proposed to protect bacteria from antibiotics, pointing to H2S-producing enzymes as possible targets for the development of antibiotic adjuvants. Here, MIC assays performed with Pseudomonas aeruginosa mutants producing altered H2S levels demonstrate that H2S does not affect antibiotic resistance in this bacterium. Moreover, correlation analyses in a large collection of P. aeruginosa cystic fibrosis isolates argue against the protective role of H2S from antibiotic activity during chronic lung infection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
