ROTILI, DANTE
 Distribuzione geografica
Continente #
AS - Asia 4.557
NA - Nord America 4.534
EU - Europa 4.115
SA - Sud America 1.263
Continente sconosciuto - Info sul continente non disponibili 216
AF - Africa 117
OC - Oceania 4
Totale 14.806
Nazione #
US - Stati Uniti d'America 4.346
NL - Olanda 1.918
SG - Singapore 1.729
RU - Federazione Russa 1.477
CN - Cina 1.212
BR - Brasile 928
VN - Vietnam 590
IT - Italia 406
BD - Bangladesh 290
HK - Hong Kong 154
KR - Corea 134
AR - Argentina 111
IN - India 100
DE - Germania 91
CA - Canada 83
EC - Ecuador 65
CO - Colombia 56
MX - Messico 51
ID - Indonesia 47
GB - Regno Unito 40
IQ - Iraq 40
ZA - Sudafrica 36
FR - Francia 35
JP - Giappone 29
TR - Turchia 29
PK - Pakistan 28
PH - Filippine 27
PY - Paraguay 26
AT - Austria 25
VE - Venezuela 24
CL - Cile 23
PL - Polonia 22
SA - Arabia Saudita 21
ES - Italia 19
UA - Ucraina 18
PE - Perù 16
UZ - Uzbekistan 16
MA - Marocco 15
JM - Giamaica 14
SE - Svezia 14
TH - Thailandia 13
EG - Egitto 12
MY - Malesia 12
AZ - Azerbaigian 11
TN - Tunisia 11
KZ - Kazakistan 10
FI - Finlandia 8
UY - Uruguay 8
CR - Costa Rica 7
DZ - Algeria 7
HN - Honduras 7
JO - Giordania 7
LT - Lituania 7
BO - Bolivia 6
AL - Albania 5
ET - Etiopia 5
IE - Irlanda 5
IL - Israele 5
KE - Kenya 5
NP - Nepal 5
OM - Oman 5
GT - Guatemala 4
LB - Libano 4
NG - Nigeria 4
PT - Portogallo 4
SY - Repubblica araba siriana 4
TW - Taiwan 4
AE - Emirati Arabi Uniti 3
AU - Australia 3
BH - Bahrain 3
CH - Svizzera 3
CI - Costa d'Avorio 3
DO - Repubblica Dominicana 3
KH - Cambogia 3
LA - Repubblica Popolare Democratica del Laos 3
LV - Lettonia 3
PA - Panama 3
QA - Qatar 3
RO - Romania 3
TT - Trinidad e Tobago 3
XK - ???statistics.table.value.countryCode.XK??? 3
BB - Barbados 2
BF - Burkina Faso 2
BG - Bulgaria 2
BS - Bahamas 2
BY - Bielorussia 2
IR - Iran 2
KW - Kuwait 2
LK - Sri Lanka 2
MG - Madagascar 2
MW - Malawi 2
PS - Palestinian Territory 2
RS - Serbia 2
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BE - Belgio 1
BN - Brunei Darussalam 1
BT - Bhutan 1
BW - Botswana 1
Totale 14.563
Città #
Amsterdam 1.866
Dallas 1.694
Singapore 785
Hefei 668
San Jose 612
Ashburn 534
Ho Chi Minh City 200
Hong Kong 143
Seoul 131
Hanoi 128
Beijing 122
New York 116
Los Angeles 105
São Paulo 93
Rome 82
Council Bluffs 78
Chicago 64
Moscow 62
Santa Clara 59
Milan 43
Orem 39
Denver 38
The Dalles 34
Da Nang 33
Atlanta 31
Brooklyn 30
Montreal 30
San Francisco 29
Seattle 27
Haiphong 25
Naples 25
Rio de Janeiro 25
Toronto 24
Falkenstein 23
Tokyo 23
Mexico City 22
Porto Alegre 21
Redondo Beach 21
Buffalo 20
Guayaquil 20
Medellín 20
Nuremberg 20
Yubileyny 20
Frankfurt am Main 19
Phoenix 19
Quito 19
Warsaw 18
Curitiba 17
Houston 17
Johannesburg 16
Tashkent 16
Brasília 15
Lahore 15
Munich 15
Tianjin 15
Asunción 14
Chennai 14
London 14
Mumbai 14
Boston 13
Buenos Aires 13
Fortaleza 13
Stockholm 13
Tampa 13
Belo Horizonte 12
Salt Lake City 12
Baghdad 11
Biên Hòa 11
Bologna 11
Lima 11
Santiago 11
Shanghai 11
Thái Bình 11
Boardman 10
Bogotá 10
Bắc Giang 10
Bắc Ninh 10
Dhaka 10
Goiânia 10
Jeddah 10
Kuala Lumpur 10
New Delhi 10
Ninh Bình 10
Salvador 10
Vienna 10
Baku 9
Caracas 9
Elk Grove Village 9
Hải Dương 9
Bangkok 8
Charlotte 8
Guarulhos 8
Hortolândia 8
Paris 8
Querétaro 8
São Gonçalo 8
Ancona 7
Belém 7
Campinas 7
Ha Long 7
Totale 8.848
Nome #
1,2,4-Oxadiazoles in medicinal chemistry: trends of the last years 2.956
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni 393
Radiofarmaco per utilizzo diagnostico terapeutico in medicina nucleare e medicina radio guidata 140
(Heteroarylmethyl)benzoic Acids as a New Class of Bacterial Cystathionine γ-Lyase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling 138
Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer 136
H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer 125
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib 119
Activation and inhibition of sirtuins: From bench to bedside 114
At long last potent and selective KDM5 inhibitors 107
Preparation of substituted quinazoline derivatives as DNA methyltransferase inhibitors 105
An Amazing 30-Year Journey around the DABO Family: A Medicinal Chemistry Lesson on a Versatile Class of Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors 105
6-[1-(2,6-difluorophenyl)ethyl]pyrimidinones antagonize cell proliferation and induce cell differentiation by inhibiting (a nontelomeric) endogenous reverse transcriptase 103
Radiodrug for diagnostic/therapeutic use in nuclear medicine and radio-guided medicine 102
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection 99
2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies 97
An improved multiplex RT–quantitative PCR assay can reveal sex-specific activity of transmission-blocking drugs on ex vivo gametocytes from Plasmodium falciparum asymptomatic infections 96
Preparation of 7-nitro-2,1,3-benzoxadiazole derivatives for antitumor therapy 96
A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast 95
HAT inhibitors in cancer therapy 95
Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives 93
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts 93
6-Alkylthio-4-[1-(2,6-difluorophenyl)alkyl]-1H-[1,3,5]triazin-2-ones (ADATs): Novel Regulators of Cell Differentiation and Proliferation 93
A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases 92
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors 92
5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile 91
A potent HDAC inhibitor blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression 91
6-(Arylmethyl)pyrimidin-4(3H)-ones: Anthology and prospects of highly efficient anti-HIV agents 88
Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5 88
KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2 85
SIRT5 regulation of ammonia-induced autophagy and mitophagy 85
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII 84
The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases 84
Mass spectrometry enables the discovery of inhibitors of an LPS transport assembly via disruption of protein–protein interactions 82
Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications 82
An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases 82
Quinoline-based p300 histone acetyltransferase inhibitors with pro-apoptotic activity in human leukemia U937 cells 81
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells 81
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability 80
GDF15-GFRAL signaling drives weight loss and lipid metabolism in mouse model of amyotrophic lateral sclerosis 80
Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains 80
Analytical and semipreparative high performance liquid chromatography separation of stereoisomers of novel 3,4-dihydropyrimidin-4(3H)-one derivatives on the immobilised amylose-based Chiralpack IA chiral stationary phase 78
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma 78
Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment 78
Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity 77
α,γ-Diketocarboxylic acids and their esters act as carbonic anhydrase IX and XII selective inhibitors 77
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells 77
Targeting lysine deacetylases (KDACs) in parasites 73
Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity in cells 73
Enzyme kinetics and inhibition of histone acetyltransferase KAT8 73
Lysine deacetylase inhibitors in parasites: past, present, and future perspectives 72
Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni 71
Structure-reactivity relationships on substrates and inhibitors of the lysine deacylase sirtuin 2 from schistosoma mansoni (SmSirt2) 70
M6A reduction relieves FUS-associated ALS granules 69
Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity 69
Histone Deacetylation in Epigenetics: An Attractive Target for Anticancer Therapy 69
Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392 68
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases 67
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities 67
Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells 67
Development of C646‐Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300 67
RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer 66
BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress 65
The Two-Faced Role of SIRT6 in Cancer 65
Effect of α-methoxy substitution on the anti-HIV activity of dihydropyrimidin-4(3 H)-ones 65
From PARP1 to TNKS2 Inhibition: A Structure-Based Approach 64
Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa 63
Carprofen Analogues as Sirtuin Inhibitors: Enzyme and Cellular Studies 63
Multimodal evaluation of 19F-BPA internalization in pancreatic cancer cells for boron capture and proton therapy potential applications 62
Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes 62
Class II-selective histone deacetylase inhibitors. Part 2: Alignment-independent GRIND 3-D QSAR, homology and docking studies 61
Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics 61
Optimization of Lipoplexes Functionalized with a Sialic Acid Mimetic (F9-PEG) to Target the C1858T PTPN22 Variant for Preclinical Assessment of a Novel Immunotherapy in Endocrine Autoimmunity 60
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni 59
Native mass spectrometry for proximity-inducing compounds: a new opportunity for studying chemical-induced protein modulation 59
Targeting histone demethylases: A new avenue for the fight against cancer 58
p300/CBP-associated factor selectively regulates the extinction of conditioned fear 58
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition 58
Prognostic Impact of H19/Cell Adhesion Molecules Circuitry on Prostate Cancer Biopsy 58
Sirtuin modulators: past, present, and future perspectives 58
Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes 58
Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile 57
Substrate-induced stable enzyme-inhibitor complex formation allows tight binding of novel 2-aminopyrimidin-4(3H)-ones to drug-resistant HIV-1 reverse transcriptase mutants 57
Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence 56
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design 56
Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription 56
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells 56
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor 56
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells 55
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression 55
Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase 55
Enhancing sensitivity of triple‐negative breast cancer to DNA‐damaging therapy through chemical inhibition of the m6A methyltransferase METTL3 54
Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer 53
Tranylcypromine‐Based LSD1 Inhibitors: Structure‐Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation 53
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells 52
Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells 52
Neuroprotective Effects of PARP Inhibitors in Drosophila Models of Alzheimer’s Disease 52
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53 51
Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies 51
Identification of novel quinazoline derivatives as potent antiplasmodial agents 51
Sirtuin functions and modulation: from chemistry to the clinic 50
Totale 10.769
Categoria #
all - tutte 45.663
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 45.663


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2024/20253.014 0 0 0 0 22 455 1.138 428 262 102 146 461
2025/202611.385 430 1.154 2.221 1.443 609 282 539 161 2.392 843 1.006 305
2026/2027407 254 153 0 0 0 0 0 0 0 0 0 0
Totale 14.806