ROTILI, DANTE
 Distribuzione geografica
Continente #
NA - Nord America 5.206
AS - Asia 4.598
EU - Europa 4.150
SA - Sud America 1.277
Continente sconosciuto - Info sul continente non disponibili 216
AF - Africa 120
OC - Oceania 4
Totale 15.571
Nazione #
US - Stati Uniti d'America 4.979
NL - Olanda 1.918
SG - Singapore 1.736
RU - Federazione Russa 1.477
CN - Cina 1.222
BR - Brasile 933
VN - Vietnam 591
IT - Italia 422
BD - Bangladesh 293
HK - Hong Kong 160
KR - Corea 134
AR - Argentina 111
CA - Canada 105
IN - India 103
DE - Germania 92
EC - Ecuador 68
CO - Colombia 61
MX - Messico 53
ID - Indonesia 50
GB - Regno Unito 47
IQ - Iraq 40
FR - Francia 37
ZA - Sudafrica 37
PK - Pakistan 30
JP - Giappone 29
PH - Filippine 29
TR - Turchia 29
AT - Austria 26
PY - Paraguay 26
CL - Cile 24
VE - Venezuela 24
ES - Italia 22
PL - Polonia 22
SA - Arabia Saudita 22
JM - Giamaica 20
UA - Ucraina 18
PE - Perù 16
UZ - Uzbekistan 16
MA - Marocco 15
SE - Svezia 14
TH - Thailandia 14
EG - Egitto 12
MY - Malesia 12
AZ - Azerbaigian 11
TN - Tunisia 11
KZ - Kazakistan 10
CR - Costa Rica 9
FI - Finlandia 8
UY - Uruguay 8
DZ - Algeria 7
HN - Honduras 7
JO - Giordania 7
LT - Lituania 7
AL - Albania 6
BO - Bolivia 6
GT - Guatemala 6
KE - Kenya 6
ET - Etiopia 5
IE - Irlanda 5
IL - Israele 5
LB - Libano 5
NP - Nepal 5
OM - Oman 5
AE - Emirati Arabi Uniti 4
NG - Nigeria 4
PT - Portogallo 4
SY - Repubblica araba siriana 4
TW - Taiwan 4
AU - Australia 3
BB - Barbados 3
BH - Bahrain 3
CH - Svizzera 3
CI - Costa d'Avorio 3
DO - Repubblica Dominicana 3
EE - Estonia 3
KH - Cambogia 3
LA - Repubblica Popolare Democratica del Laos 3
LV - Lettonia 3
PA - Panama 3
QA - Qatar 3
RO - Romania 3
TT - Trinidad e Tobago 3
XK - ???statistics.table.value.countryCode.XK??? 3
BF - Burkina Faso 2
BG - Bulgaria 2
BS - Bahamas 2
BY - Bielorussia 2
CZ - Repubblica Ceca 2
GP - Guadalupe 2
IR - Iran 2
KW - Kuwait 2
KY - Cayman, isole 2
LK - Sri Lanka 2
MG - Madagascar 2
MW - Malawi 2
NI - Nicaragua 2
PS - Palestinian Territory 2
RS - Serbia 2
SV - El Salvador 2
AM - Armenia 1
Totale 15.326
Città #
Amsterdam 1.866
Dallas 1.698
Singapore 791
Hefei 668
San Jose 636
Ashburn 634
Ho Chi Minh City 200
Council Bluffs 181
Hong Kong 148
Seoul 131
Hanoi 129
Beijing 127
New York 120
Los Angeles 110
São Paulo 94
Rome 86
Santa Clara 80
Chicago 68
Moscow 62
Phoenix 51
Milan 45
Denver 39
Orem 39
Atlanta 36
San Francisco 35
The Dalles 34
Da Nang 33
Montreal 33
Brooklyn 32
Seattle 27
Toronto 27
Haiphong 25
Naples 25
Rio de Janeiro 25
Buffalo 23
Falkenstein 23
Tokyo 23
Mexico City 22
Guayaquil 21
Nuremberg 21
Porto Alegre 21
Redondo Beach 21
Medellín 20
Yubileyny 20
Frankfurt am Main 19
Quito 19
Curitiba 18
Houston 18
Warsaw 18
Johannesburg 17
Brasília 16
Tashkent 16
Boston 15
Lahore 15
Munich 15
Tianjin 15
Asunción 14
Chennai 14
London 14
Mumbai 14
Tampa 14
Buenos Aires 13
Fortaleza 13
Stockholm 13
Belo Horizonte 12
Bogotá 12
Salt Lake City 12
Santiago 12
Baghdad 11
Biên Hòa 11
Bologna 11
Kingston 11
Lima 11
New Delhi 11
Shanghai 11
Thái Bình 11
Vienna 11
Boardman 10
Bắc Giang 10
Bắc Ninh 10
Charlotte 10
Dhaka 10
Elk Grove Village 10
Goiânia 10
Jeddah 10
Kuala Lumpur 10
Ninh Bình 10
Salvador 10
Baku 9
Caracas 9
Hải Dương 9
Paris 9
Bangkok 8
Guarulhos 8
Hortolândia 8
Querétaro 8
São Gonçalo 8
Ancona 7
Belém 7
Campinas 7
Totale 9.214
Nome #
1,2,4-Oxadiazoles in medicinal chemistry: trends of the last years 2.967
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni 396
Activation and inhibition of sirtuins: From bench to bedside 146
(Heteroarylmethyl)benzoic Acids as a New Class of Bacterial Cystathionine γ-Lyase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling 141
Radiofarmaco per utilizzo diagnostico terapeutico in medicina nucleare e medicina radio guidata 141
Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer 138
H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer 129
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib 123
Preparation of substituted quinazoline derivatives as DNA methyltransferase inhibitors 108
At long last potent and selective KDM5 inhibitors 108
An Amazing 30-Year Journey around the DABO Family: A Medicinal Chemistry Lesson on a Versatile Class of Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors 108
6-[1-(2,6-difluorophenyl)ethyl]pyrimidinones antagonize cell proliferation and induce cell differentiation by inhibiting (a nontelomeric) endogenous reverse transcriptase 107
Radiodrug for diagnostic/therapeutic use in nuclear medicine and radio-guided medicine 107
An improved multiplex RT–quantitative PCR assay can reveal sex-specific activity of transmission-blocking drugs on ex vivo gametocytes from Plasmodium falciparum asymptomatic infections 102
A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast 101
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection 101
HAT inhibitors in cancer therapy 101
Preparation of 7-nitro-2,1,3-benzoxadiazole derivatives for antitumor therapy 100
2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies 99
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts 98
5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile 96
Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives 96
6-Alkylthio-4-[1-(2,6-difluorophenyl)alkyl]-1H-[1,3,5]triazin-2-ones (ADATs): Novel Regulators of Cell Differentiation and Proliferation 96
A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases 95
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors 95
A potent HDAC inhibitor blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression 92
SIRT5 regulation of ammonia-induced autophagy and mitophagy 91
An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases 90
6-(Arylmethyl)pyrimidin-4(3H)-ones: Anthology and prospects of highly efficient anti-HIV agents 90
Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5 89
Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications 88
The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases 88
KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2 87
Mass spectrometry enables the discovery of inhibitors of an LPS transport assembly via disruption of protein–protein interactions 86
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII 85
Analytical and semipreparative high performance liquid chromatography separation of stereoisomers of novel 3,4-dihydropyrimidin-4(3H)-one derivatives on the immobilised amylose-based Chiralpack IA chiral stationary phase 83
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells 83
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma 83
Quinoline-based p300 histone acetyltransferase inhibitors with pro-apoptotic activity in human leukemia U937 cells 82
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability 82
GDF15-GFRAL signaling drives weight loss and lipid metabolism in mouse model of amyotrophic lateral sclerosis 82
Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains 82
Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment 81
α,γ-Diketocarboxylic acids and their esters act as carbonic anhydrase IX and XII selective inhibitors 81
Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity 80
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells 80
Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity in cells 77
Targeting lysine deacetylases (KDACs) in parasites 76
Enzyme kinetics and inhibition of histone acetyltransferase KAT8 76
Lysine deacetylase inhibitors in parasites: past, present, and future perspectives 74
Structure-reactivity relationships on substrates and inhibitors of the lysine deacylase sirtuin 2 from schistosoma mansoni (SmSirt2) 73
Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392 73
Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni 73
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities 73
Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity 73
Development of C646‐Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300 73
Histone Deacetylation in Epigenetics: An Attractive Target for Anticancer Therapy 72
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases 71
RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer 70
M6A reduction relieves FUS-associated ALS granules 70
Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells 69
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition 68
The Two-Faced Role of SIRT6 in Cancer 68
Multimodal evaluation of 19F-BPA internalization in pancreatic cancer cells for boron capture and proton therapy potential applications 67
Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa 67
BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress 67
Effect of α-methoxy substitution on the anti-HIV activity of dihydropyrimidin-4(3 H)-ones 66
From PARP1 to TNKS2 Inhibition: A Structure-Based Approach 65
Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes 65
Carprofen Analogues as Sirtuin Inhibitors: Enzyme and Cellular Studies 65
Class II-selective histone deacetylase inhibitors. Part 2: Alignment-independent GRIND 3-D QSAR, homology and docking studies 64
p300/CBP-associated factor selectively regulates the extinction of conditioned fear 64
Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics 64
Sirtuin modulators: past, present, and future perspectives 64
Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile 62
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design 62
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni 62
Optimization of Lipoplexes Functionalized with a Sialic Acid Mimetic (F9-PEG) to Target the C1858T PTPN22 Variant for Preclinical Assessment of a Novel Immunotherapy in Endocrine Autoimmunity 62
Targeting histone demethylases: A new avenue for the fight against cancer 61
Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence 61
Prognostic Impact of H19/Cell Adhesion Molecules Circuitry on Prostate Cancer Biopsy 61
Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes 61
Native mass spectrometry for proximity-inducing compounds: a new opportunity for studying chemical-induced protein modulation 61
Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription 60
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor 60
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells 59
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells 59
Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase 59
Substrate-induced stable enzyme-inhibitor complex formation allows tight binding of novel 2-aminopyrimidin-4(3H)-ones to drug-resistant HIV-1 reverse transcriptase mutants 59
Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells 58
Enhancing sensitivity of triple‐negative breast cancer to DNA‐damaging therapy through chemical inhibition of the m6A methyltransferase METTL3 58
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression 58
Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer 57
Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies 56
Identification of novel quinazoline derivatives as potent antiplasmodial agents 56
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53 55
Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer 55
Tranylcypromine‐Based LSD1 Inhibitors: Structure‐Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation 55
I kappa B kinase (IKK)-epsilon targets interferon regulatory factor 1 in activated T lymphocytes 55
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells 54
Totale 11.157
Categoria #
all - tutte 49.335
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 49.335


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2024/20253.014 0 0 0 0 22 455 1.138 428 262 102 146 461
2025/202611.385 430 1.154 2.221 1.443 609 282 539 161 2.392 843 1.006 305
2026/20271.172 254 316 584 18 0 0 0 0 0 0 0 0
Totale 15.571